The state of the immune system in abdominal sepsis
| Autor: | A V Vatazin, A B Zulkarnayev, R V Koshelev, A P Faenko |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Lipopolysaccharides
0301 basic medicine History endotoxins Lipopolysaccharide Endocrinology Diabetes and Metabolism Phagocytosis medicine.medical_treatment CD3 neutrophil activity lcsh:Medicine Pathogenesis Sepsis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Gram-Negative Bacteria Humans Medicine Prospective Studies 030212 general & internal medicine biology Tumor Necrosis Factor-alpha business.industry lcsh:R General Medicine medicine.disease 030104 developmental biology Cytokine chemistry cytotoxins Immunology biology.protein Cytokines Tumor necrosis factor alpha Family Practice business |
| Zdroj: | Терапевтический архив, Vol 91, Iss 2, Pp 82-86 (2019) |
| ISSN: | 2309-5342 0040-3660 |
| DOI: | 10.26442/00403660.2019.02.000064 |
| Popis: | Sepsis is a serious condition characterized by a complex dysfunction of internal organs and systems. In the basis of the pathogenesis of sepsis, the leading role is played by the dysregulation of the immune response to the infectious agent, in particular endotoxin of gramnegative bacteria, which is an obligate lipopolysaccharide of the bacterial wall. Aim. To evaluate the prognostic value of cytokine profile, phagocytosis activity indices, endotoxin concentration and activity in blood in gram-negative sepsis. Materials and methods. 78 patients with abdominal sepsis were included in a one-center prospective cohort study, of them 45 died. All the patients were evaluated for the concentration of circulating cytokines (TNF-α, IFN-γ, IL-6, IL-8, IL-10), cellular molecules (CD3, CD45RO, CD95 and HLA-DR), bactericidal and phagocytic activity of neutrophils and endotoxin (lipopolysaccharide) level in peripheral blood. Results and discussion. The concentrations of all cytokines were slightly lower in the survivors. Significant differences were noted for TNF-α (p=0.001), IL-6 (p=0.001), and IL-8 (p=0.007). The expression of HLA-DR molecules was slightly higher (p=0.055), and CD95 was lower (p=0.146) in survivors than in the dead. However, the differences have not reached the required level of statistical significance. The phagocytic (p |
| Databáze: | OpenAIRE |
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