Anti-inflammatory activity of naturally occuring diarylheptanoids – A review
| Autor: | Corinne Vanucci-Bacqué, Florence Bedos-Belval |
|---|---|
| Přispěvatelé: | Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
Clinical Biochemistry inflammatory mediator Pharmaceutical Science Inflammation [CHIM.THER]Chemical Sciences/Medicinal Chemistry Pharmacology 01 natural sciences Biochemistry Anti-inflammatory Pharmacotherapy Immune system Diarylheptanoids In vivo Drug Discovery medicine Humans anti-inflammatory activity Medicinal plants Molecular Biology Biological Products Molecular Structure 010405 organic chemistry Chemistry natural diarylheptanoids Anti-Inflammatory Agents Non-Steroidal Organic Chemistry In vitro 0104 chemical sciences 3. Good health 010404 medicinal & biomolecular chemistry macrocycles Molecular Medicine medicine.symptom |
| Zdroj: | Bioorganic and Medicinal Chemistry Bioorganic and Medicinal Chemistry, 2021, 31, pp.115971. ⟨10.1016/j.bmc.2020.115971⟩ Bioorganic and Medicinal Chemistry, Elsevier, 2021, 31, pp.115971. ⟨10.1016/j.bmc.2020.115971⟩ |
| ISSN: | 0968-0896 1464-3391 |
| DOI: | 10.1016/j.bmc.2020.115971 |
| Popis: | International audience; Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, if it becomes uncontrolled, inflammation may result in autoimmune or auto inflammatory disorders, neurodegenerative diseases or cancers. The currently available anti-inflammatory drug therapy is often not successful or induces severe side effects. Thus, the search of new therapeutic options for the treatment of inflammation is highly required. Medicinal plants have been an interesting source for obtaining new active compounds. Diarylheptanoids characterized by a 1, 7-diphenylheptane structural skeleton, are a class of secondary plant metabolites that have gained increasing interest over the last few decades due to a wide variety of biological activities. This review covers 182 natural linear or macrocyclic diarylheptanoids described in the period of 1982 to 2020 with anti-inflammatory activities evaluated using quantified in vitro and/or in vivo assays. All of these data highlight the pharmacological potential of these natural compounds to act as anti-inflammatory drugs. |
| Databáze: | OpenAIRE |
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