Association of right ventricular dysfunction and pulmonary hypertension with adverse 30‐day outcomes in COVID‐19 patients
| Autor: | Adnan Sadiq, Manfred Moskovits, Daniel Rodriguez, Joshua Fogel, Jessen Jacob, Mark Goldberger, Mahsa Pourabdollah Tootkaboni, Jacob Shani, Karan Wats, Kurt W. Prins |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
2019-20 coronavirus outbreak medicine.medical_specialty RC705-779 Coronavirus disease 2019 (COVID-19) business.industry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 medicine.disease Pulmonary hypertension Right ventricular dysfunction Diseases of the respiratory system RC666-701 Internal medicine pulmonary hypertension medicine Cardiology Diseases of the circulatory (Cardiovascular) system echocardiography right ventricular dysfunction Original Research Article business Value (mathematics) |
| Zdroj: | Pulmonary Circulation Pulmonary Circulation, Vol 11 (2021) |
| ISSN: | 2045-8940 |
| DOI: | 10.1177/20458940211007040 |
| Popis: | Background Cardiac manifestations in COVID-19 are multifactorial and are associated with increased mortality. The clinical utility and prognostic value of echocardiography in COVID-19 inpatients is not clearly defined. We aim to identify echocardiographic parameters that are associated with 30-day clinical outcomes secondary to COVID-19 hospitalization. Methods This retrospective cohort study was conducted in a large tertiary hospital in New York City during the COVID-19 pandemic. It included 214 adult inpatients with a laboratory-confirmed diagnosis of COVID-19 by reverse transcriptase polymerase chain reaction assay (RT-PCR) for SARS-CoV-2 on nasopharyngeal swab and had a transthoracic echocardiogram performed during the index hospitalization. Primary outcome was 30-day all-cause inpatient mortality. Secondary outcomes were 30-day utilization of mechanical ventilator support, vasopressors, or renal replacement therapy. Results Mild right ventricular systolic dysfunction (odds ratio (OR): 3.51, 95% confidence interval (CI): 1.63–7.57, p = 0.001), moderate to severe right ventricular systolic dysfunction (OR: 7.30, 95% CI: 2.20–24.25, p = 0.001), pulmonary hypertension (OR: 5.39, 95% CI: 1.96–14.86, p = 0.001), and moderate to severe tricuspid regurgitation (OR: 3.92, 95% CI: 1.71–9.03, p = 0.001) were each associated with increased odds of 30-day all-cause inpatient mortality. Pulmonary hypertension and moderate to severe right ventricular dysfunction were each associated with increased odds of 30-day utilization of mechanical ventilator support and vasopressors. Conclusions Right ventricular dysfunction, pulmonary hypertension, and moderate to severe tricuspid regurgitation were associated with increased odds for 30-day inpatient mortality. This study highlights the importance of echocardiography and its clinical utility and prognostic value for evaluating hospitalized COVID-19 patients. |
| Databáze: | OpenAIRE |
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