Metal-free (Boc)2O-mediated C4-selective direct indolation of pyridines using TEMPO

Autor:	Wenbing Qin, Yubo Kong, Yun-Hong Bao, Liang-Xian Liu, Zhengwang Chen, Jiayi Zhu
Rok vydání:	2014
Předmět:	Indoles Alkylation Pyridines Chemistry Organic Chemistry Carbonates Stereoisomerism Oxidation reduction Biochemistry humanities Cyclic N-Oxides Metal free Metals Surface modification Organic chemistry Physical and Theoretical Chemistry Oxidation-Reduction
Zdroj:	Org. Biomol. Chem.. 12:4252-4259
ISSN:	1477-0539 1477-0520
Popis:	Direct metal-free C-4-selective indolation of pyridines is achieved for the first time using TEMPO and (Boc)2O. A variety of substituents on both indoles and pyridines are tolerated to give 3-(pyridin-4-yl)-1H-indole derivatives in moderate to excellent yields. This finding provides a novel approach for developing metal-free C-H functionalization of pyridines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a42295cc1e1a7484863c0820f4d1ad https://doi.org/10.1039/c4ob00356j Zobrazit plný text záznamu