Epidemiological characteristics, management and early outcomes of acute coronary syndromes in Greece: The PHAETHON study

Autor: Dimitrios Alexopoulos, V. Vasilikos, Stefanos G. Foussas, Georgios Andrikopoulos, Ioannis H. Styliadis, Nikolaos Fragakis, S. Zombolos, Stylianos Tzeis, S. Lymperi, C. Vlachopoulos, P. Andronikos, John Lekakis, Nikos Nikas, Christos Kyrpizidis, Κ. Oikonomou, Α. Dermitzakis, Dimitrios Terentes-Printzios, S. Mavridis, Dimitrios J. Richter, Christos Varounis, D. Symeonidis, Α. Κranidis, Panagiotis Vardas, D.N. Chrissos, Dimitrios Stakos, Christodoulos Stefanadis
Jazyk: angličtina
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Acute coronary syndrome
Epidemiology
medicine.medical_treatment
030204 cardiovascular system & hematology
Acute coronary syndromes
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Angina
Unstable
Prospective Studies
030212 general & internal medicine
Myocardial infarction
Acute Coronary Syndrome
Non-ST Elevated Myocardial Infarction
Intensive care medicine
Prospective cohort study
Aged
Medicine(all)
Greece
business.industry
Percutaneous coronary intervention
Middle Aged
medicine.disease
Prognosis
Health Surveys
lcsh:RC666-701
Cohort
ST Elevation Myocardial Infarction
Female
Cardiology and Cardiovascular Medicine
business
Cohort study
Zdroj: Hellenic Journal of Cardiology, Vol 57, Iss 3, Pp 157-166 (2016)
ISSN: 1109-9666
DOI: 10.1016/j.hjc.2016.06.003
Popis: Introduction In view of recent therapeutic breakthroughs in acute coronary syndromes (ACS) and essential demographic and socioeconomic changes in Greece, we conducted the prospective, multi-center, nationwide PHAETHON study (An Epidemiological Cohort Study of Acute Coronary Syndromes in the Greek Population) that aimed to recruit a representative cohort of ACS patients and examine current management practices and patient prognosis. Methods The PHAETHON study was conducted from May 2012 to February 2014. We enrolled 800 consecutive ACS patients from 37 hospitals with a proportional representation of all types of hospitals and geographical areas. Patients were followed for a median period of 189 days. Outcome was assessed with a composite endpoint of death, myocardial infarction, stroke, urgent revascularization and urgent hospitalization for cardiovascular causes. Results The mean age of patients was 62.7 years (78% males). The majority of patients (n=411, 51%) presented with ST-elevation myocardial infarction (STEMI), whereas 389 patients presented with NSTEMI (n=303, 38%) or UA (n=86, 11%). Overall, 58.8% of the patients had hypertension, 26.5% were diabetic, 52.5% had dyslipidemia, 71.1% had a smoking history (current or past), 25.8% had a family history of coronary artery disease (CAD) and 24.1% had a prior history of CAD. In STEMI patients, 44.5% of patients were treated with thrombolysis, 38.9% underwent a coronary angiogram (34.1% were treated with primary percutaneous coronary intervention) and 16.5% did not receive urgent treatment. The pain-to-door time was 169 minutes. During hospitalization, 301 (38%) patients presented one or more complications, and 13 died (1.6%). During follow-up, 99 (12.6%) patients experienced the composite endpoint, and 21 died (2.7%). Conclusions The PHAETHON study provided valuable insights into the epidemiology, management and outcome of ACS patients in Greece. Management of ACS resembles the management observed in other European countries. However, several issues still to be addressed by public authorities for the timely and proper management of ACS.
Databáze: OpenAIRE
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