Heparin adsorbing capacities at physiological pH of three poly(amido-amine) resins, and of poly(amido-amine)-surface-grafted glass microspheres
| Autor: | S Sancasciani, M. A. Marchisio, Maria Cristina Tanzi, M. C. Beni, P. Ferruti, E Dispensa, I Domini, Rolando Barbucci |
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| Rok vydání: | 1983 |
| Předmět: |
Materials science
Biophysics Bioengineering Biomaterials Adsorption Polymer chemistry medicine chemistry.chemical_classification Elution Heparin Polymer Hydrogen-Ion Concentration Haemolysis Microspheres Glass microsphere Nylons Resins Synthetic chemistry Mechanics of Materials Ceramics and Composites Amine gas treating Glass After treatment medicine.drug |
| Zdroj: | Biomaterials. 4(3) |
| ISSN: | 0142-9612 |
| Popis: | Three poly(amido-amine)s of similar structure in the form of highly hydrophilic crosslinked resins, have been prepared, and tested for their heparin-adsorbing capacity at physiological pH. They showed different capacities, and their capacities were related to their basicities. One of the same polymers was grafted on the surface of glass microspheres. After treatment, it was shown that the microspheres could adsorb significant amounts of heparin. In all cases most of the adsorbed heparin was hardly eluted with saline, plasma, or blood, but could be recovered by eluting with 0.1 M NaOH. The resins were found to have some haemolytic properties, but no haemolysis was observed with the grafted microspheres. |
| Databáze: | OpenAIRE |
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