Acetyl-L-carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver
| Autor: | Vittoria Petruzzella, M. N. Gadaleta, P. Fernandez-Silva, Palmiro Cantatore, Flavio Fracasso |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Mitochondrial DNA transcription Biophysics Gene Expression Mitochondria Liver Mitochondrion Biochemistry DNA Mitochondrial Electron Transport Complex IV Hypothyroidism Structural Biology Internal medicine Gene expression Genetics medicine Cytochrome c oxidase Animals Hypothyroid rat liver Northern blot Carnitine Molecular Biology Messenger RNA Oxidase test biology Nucleic Acid Hybridization Rats Inbred Strains Cell Biology Molecular biology Acetyl-L-carnitine Rats Endocrinology biology.protein Solution hybridization Triiodothyronine Acetylcarnitine medicine.drug |
| Zdroj: | FEBS letters. 277(1-2) |
| ISSN: | 0014-5793 |
| Popis: | The effect of acetyl-L-carnitine on the quantity of the messenger RNA for the subunit I of cytoehrome oxidase in the liver mitochondria of hypothyroid rat was measured by Northern blot and solution hybridization. Three hours after pre-treatment of hypothyroid rat with acetyl-L-carnitine, the level of the transcript increased strongly. This effect was also obtained when acetyl-L-carnitine was administered to T3 pre-treated hypothyroid rats. These results add further evidence to the suggestion that acetyl-L-camitine is able to stimulate mitochondrial transcription under altered metabolic conditions. |
| Databáze: | OpenAIRE |
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