Polymorphism in toll-like receptors and helicobacter pylori motility in autoimmune atrophic gastritis and gastric cancer
| Autor: | Vincenzo Canzonieri, Mariangela De Zorzi, Paolo Giuffrida, Gianmaria Miolo, Valli De Re, Laura Caggiari, Ombretta Repetto, Agostino Steffan, Antonio Di Sabatino, Lara Alessandrini, Mariateresa Casarotto, Stefania Zanussi, Giorgio Zanette, Cinzia Mazzon, Raffaella Magris, Renato Cannizzaro, Massimo Tedeschi, Marco Vincenzo Lenti |
|---|---|
| Přispěvatelé: | De Re, V., Repetto, O., De Zorzi, M., Casarotto, M., Tedeschi, M., Giuffrida, P., Lenti, M. V., Magris, R., Miolo, G., Mazzon, C., Zanette, G., Alessandrini, L., Canzonieri, V., Caggiari, L., Zanussi, S., Steffan, A., Di Sabatino, A., Cannizzaro, R. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Toll-like receptor 9 (TLR9) Atrophic gastritis Autoimmune Gastritis lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Immune system medicine polycyclic compounds Toll-like receptor 5 (TLR5) biology Autoimmune gastritis Flagellin A Helicobacter pylori TLR9 Autoimmune gastriti lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease biology.organism_classification Acquired immune system female genital diseases and pregnancy complications 030104 developmental biology Oncology TLR5 030220 oncology & carcinogenesis Immunology biology.protein Flagellin |
| Zdroj: | Cancers Volume 11 Issue 5 Cancers, Vol 11, Iss 5, p 648 (2019) |
| Popis: | Autoimmune atrophic gastritis (AAG) is associated with an increased risk of certain types of gastric cancer (GC). Helicobacter pylori (H. pylori) infection may have a role in the induction and/or maintenance of AAG and GC. Toll-like receptors (TLR) are essential for H. pylori recognition and subsequent innate and adaptive immunity responses. This study therefore aimed to characterize TLR polymorphisms, and features of bacterial flagellin A in samples from patients with AAG (n = 67), GC (n = 114) and healthy donors (HD n = 97). TLR5 rs5744174 C/C genotype was associated with GC, lower IgG anti H. pylori response and a higher H. pylori flagellin A abundance and motility. In a subset of patients with AAG, H. pylori strains showed a reduction of the flagellin A abundance and a moderate motility compared with strains from GC patients, a prerequisite for active colonization of the deeper layers of the mucosa, host immune response and inflammation. TLR9 rs5743836 T allele showed an association with serum gastrin G17. In conclusion, our study suggests that alterations of flaA protein, moderate motility in H. pylori and two polymorphisms in TLR5 and TLR9 may favor the onset of AAG and GC, at least in a subset of patients. These findings corroborate the function of pathogen&ndash host cell interactions and responses, likely influencing the pathogenetic process. |
| Databáze: | OpenAIRE |
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