The effect of Korean Red Ginseng extract on rosiglitazone-induced improvement of glucose regulation in diet-induced obese mice
| Autor: | Na Hee Ha, Sang Hyun Choi, Dong Hoon Kim, Hyun Ju Kim, Eun Young Park, Boe Gwun Chun, Mi Jeong Oh, Myung Gyu Song |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Korean Red Ginseng Adipose tissue glucose regulation Biochemistry Genetics and Molecular Biology (miscellaneous) rosiglitazone 03 medical and health sciences Ginseng 0302 clinical medicine Internal medicine Diabetes mellitus lcsh:Botany Medicine Receptor business.industry medicine.disease adipose tissue lcsh:QK1-989 Reverse transcription polymerase chain reaction 030104 developmental biology Endocrinology Complementary and alternative medicine inflammation 030220 oncology & carcinogenesis Blood sugar regulation business Rosiglitazone Diet-induced obese Biotechnology medicine.drug Research Article |
| Zdroj: | Journal of Ginseng Research, Vol 41, Iss 1, Pp 52-59 (2017) Journal of Ginseng Research |
| ISSN: | 1226-8453 |
| DOI: | 10.1016/j.jgr.2015.12.011 |
| Popis: | Background Korean Red Ginseng extract (KRG, Panax ginseng Meyer) and its constituents have been used for treating diabetes. However, in diet-induced obese mice, it is unclear whether KRG can enhance the glucose-lowering action of rosiglitazone (ROSI), a peroxisome proliferator-activated receptor gamma synthetic activator. Methods Oral glucose tolerance tests (oGTTs) were performed after 4 days of treatment with a vehicle (CON), KRG [500 mg/kg body weight (b.w.)], ROSI (3.75 mg/kg b.w, 7.5 mg/kg b.w, and 15 mg/kg b.w.), or ROSI and KRG (RK) in obese mice on a high-fat diet. Adipose tissue morphology, crown-like structures (CLSs), and inflammation were compared by hematoxylin-eosin staining or quantitative reverse transcription polymerase chain reaction. Results The area under the glucose curve (AUC) was significantly lower in the RK group (15 mg/kg b.w. and 500 mg/kg b.w. for ROSI and KRG, respectively) than in the CON group. There was no significant difference in the AUC between the CON and the other groups. Furthermore, the AUC was significantly lower in the RK group than in the ROSI group. The expression of the Ccl2 gene and the number of CLSs were significantly reduced in the RK group than in the CON group. Conclusion Our results show a potential enhancement of ROSI-induced improvement of glucose regulation by the combined treatment with KRG. |
| Databáze: | OpenAIRE |
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