Insights into in vivo follicle formation: a review of in vitro systems
| Autor: | Shinya Ikeda, Yayoi Obata, Ren Tanimoto, Kyota Yoshida |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Anti-Mullerian Hormone
Histology medicine.drug_class Oogenesis Mice Follicle Ovarian Follicle In vivo medicine Animals Molecular Biology Mammals biology Ovary Anti-Müllerian hormone Cell Biology Oocyte Cell biology Medical Laboratory Technology medicine.anatomical_structure Estrogen Oocytes biology.protein Female Developmental biology Hormone |
| Zdroj: | Histochemistry and Cell Biology. 157:333-345 |
| ISSN: | 1432-119X 0948-6143 |
| DOI: | 10.1007/s00418-021-02058-w |
| Popis: | In vitro systems capable of reconstituting the process of mouse oogenesis are now being established to help develop further understanding of the mechanisms underlying oocyte/follicle development and differentiation. These systems could also help increase the production of useful livestock or genetically modified animals, and aid in identifying the causes of infertility in humans. Recently, we revealed, using an in vitro system for recapitulating oogenesis, that the activation of the estrogen signaling pathway induces abnormal follicle formation, that blocking estrogen-induced expression of anti-Müllerian hormone is crucial for normal follicle formation, and that the production of α-fetoprotein in fetal liver tissue is involved in normal in vivo follicle formation. In mouse fetuses, follicle formation is not carried out by factors within the ovaries but is instead orchestrated by distal endocrine factors. This review outlines findings from genetics, endocrinology, and in vitro studies regarding the factors that can affect the formation of primordial follicles in mammals. |
| Databáze: | OpenAIRE |
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