The Effect of Three Mediterranean Diets on Remnant Cholesterol and Non-Alcoholic Fatty Liver Disease: A Secondary Analysis

Autor: Paolo Sorino, Antonella Mirizzi, Giovanni Misciagna, Alberto Rubén Osella, Anna Maria Cisternino, Claudia Buongiorno, Antonella Bianco, Isabella Franco, Palma Aurelia Iacovazzi, Angelo Campanella, Rosalba Liuzzi, Maria Gabriella Caruso, Caterina Bonfiglio
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
Time Factors
Mediterranean diet
lcsh:TX341-641
Disease
030204 cardiovascular system & hematology
Diet
Mediterranean
Gastroenterology
Severity of Illness Index
Article
law.invention
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Insulin resistance
Randomized controlled trial
fasting REM-C levels
law
Non-alcoholic Fatty Liver Disease
Internal medicine
Secondary analysis
insulin resistance
medicine
NAFLD severity score
Humans
Nutritional Physiological Phenomena
030212 general & internal medicine
Aged
Aged
80 and over
Metabolic Syndrome
Nutrition and Dietetics
business.industry
Cholesterol
musculoskeletal
neural
and ocular physiology
Fatty liver
Middle Aged
medicine.disease
chemistry
Female
Metabolic syndrome
business
lcsh:Nutrition. Foods and food supply
Biomarkers
Food Science
Follow-Up Studies
Zdroj: Nutrients
Volume 12
Issue 6
Nutrients, Vol 12, Iss 1674, p 1674 (2020)
ISSN: 2072-6643
Popis: Background: Elevated fasting remnant cholesterol (REM-C) levels have been associated with an increased cardiovascular risk in patients with metabolic syndrome (Mets) and Non-Alcoholic Fatty Liver Disease (NAFLD). We aimed to estimate the effect of different diets on REM-C levels in patients with MetS, as well as the association between NAFLD and REM-C. Methods: This is a secondary analysis of the MEDIDIET study, a parallel-arm Randomized Clinical Trial (RCT). We examined 237 people with MetS who underwent Liver Ultrasound (LUS) to assess the NAFLD score at baseline, 3-, and 6-months follow-up. Subjects were randomly assigned to the Mediterranean diet (MD), Low Glycemic Index diet (LGID), or Low Glycemic Index Mediterranean diet (LGIMD). REM-C was calculated as [total cholesterol&ndash
low density lipoprotein cholesterol (LDL-C)&ndash
high density lipoprotein cholesterol (HDL-C)]. Results: REM-C levels were higher in subjects with moderate or severe NAFLD than in mild or absent ones. All diets had a direct effect in lowering the levels of REM-C after 3 and 6 months of intervention. In adherents subjects, this effect was stronger among LGIMD as compared to the control group. There was also a significant increase in REM-C levels among Severe NAFLD subjects at 3 months and a decrease at 6 months. Conclusions: fasting REM-C level is independently associated with the grade of severity of NAFLD. LGIMD adherence directly reduced the fasting REM-C in patients with MetS.
Databáze: OpenAIRE
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