Development of benzodioxine-heteroarylpiperazines as highly potent and selective α2c antagonists

Autor:	Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Rok vydání:	2022
Předmět:	Receptors Adrenergic alpha-2 Organic Chemistry Clinical Biochemistry Drug Discovery Pharmaceutical Science Molecular Medicine Molecular Biology Biochemistry
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 77:129005
ISSN:	0960-894X
Popis:	Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candidate molecules.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79817adb5e1c73186ea6f167f3ba422 https://doi.org/10.1016/j.bmcl.2022.129005 Zobrazit plný text záznamu Full Text from ScienceDirect