Enabling cytoplasmic delivery and organelle targeting by surface modification of nanocarriers
| Autor: | Parodi, A, Corbo, C, Cevenini, A, Molinaro, R, Palomba, R, Pandolfi, L, Agostini, M, Salvatore, F, Tasciotti, E |
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| Přispěvatelé: | Alessandro, Parodi, Corbo, Claudia, Cevenini, Armando, Roberto, Molinaro, Roberto Palomba, Laura, Pandolfi, Marco Agostini, Salvatore, Francesco, Ennio, Tasciotti, Parodi, A, Corbo, C, Cevenini, A, Molinaro, R, Palomba, R, Pandolfi, L, Agostini, M, Salvatore, F, Tasciotti, E |
| Rok vydání: | 2015 |
| Předmět: |
Biocompatible
Cytoplasm cell surface modifications Surface Properties Endosome media_common.quotation_subject Cell Biomedical Engineering Medicine (miscellaneous) Bioengineering Nanotechnology Context (language use) Review Development Biology biological barriers intracellular targeting nanocarriers nanomedicine Coated Materials Biocompatible Animals Drug Design Humans Materials Testing Nanocapsules Organelles medicine General Materials Science Internalization biological barrier media_common Coated Materials cell surface modification 3. Good health Cell biology medicine.anatomical_structure nanocarrier Nanomedicine Nanocarriers Intracellular |
| Zdroj: | Nanomedicine |
| ISSN: | 1748-6963 1743-5889 |
| DOI: | 10.2217/nnm.15.39 |
| Popis: | Nanocarriers are designed to specifically accumulate in diseased tissues. In this context, targeting of intracellular compartments was shown to enhance the efficacy of many drugs and to offer new and more effective therapeutic approaches. This is especially true for therapies based on biologicals that must be encapsulated to favor cell internalization, and to avoid intracellular endosomal sequestration and degradation of the payload. In this review, we discuss specific surface modifications designed to achieve cell cytoplasm delivery and to improve targeting of major organelles; we also discuss the therapeutic applications of these approaches. Last, we describe some integrated strategies designed to sequentially overcome the biological barriers that separate the site of administration from the cell cytoplasm, which is the drug's site of action. |
| Databáze: | OpenAIRE |
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