Cerebral perfusion disturbances in chronic mild traumatic brain injury correlate with psychoemotional outcomes

Autor: Emmanouil Papastefanakis, Styliani Papadopoulou, Alexandros Zampetakis, Eleftherios Kavroulakis, Katina Manolitsi, Efrosini Papadaki, Panagiotis G. Simos, Antonios Vakis, Pelagia Tsagaraki, Margarita Malliou, Dimitrios Makrakis
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Traumatic brain injury
Cognitive Neuroscience
Population
Hippocampus
050105 experimental psychology
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
0302 clinical medicine
Internal medicine
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Neuropsychological assessment
Cerebral perfusion pressure
education
Brain Concussion
Depression (differential diagnoses)
education.field_of_study
medicine.diagnostic_test
business.industry
05 social sciences
Brain
medicine.disease
Magnetic Resonance Imaging
Perfusion
Psychiatry and Mental health
Neurology
Cerebral blood flow
Cerebrovascular Circulation
Cardiology
Anxiety
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Zdroj: Brain Imaging and Behavior. 15:1438-1449
ISSN: 1931-7565
1931-7557
DOI: 10.1007/s11682-020-00343-1
Popis: The study explored associations between hemodynamic changes and psychoemotional status in 32 patients with chronic mild traumatic brain injury (mTBI) and 31 age-matched healthy volunteers. Cerebral blood flow (CBF) and cerebral blood volume (CBV) values were obtained using Dynamic Susceptibility Contrast Magnetic Resonance Imaging in brain regions suspected to play a role in anxiety and depression. Patients were administered self-report measures of anxiety and depression symptoms and underwent neuropsychological assessment. As a group mTBI patients scored significantly below age- and education-adjusted population norms on multiple cognitive domains and reported high rates of anxiety and depression symptomatology. Significantly reduced CBF values were detected in the mTBI group compared to controls in dorsolateral prefrontal areas, putamen, and hippocampus, bilaterally. Within the mTBI group, depressive symptomatology was significantly associated with lower perfusion in the left anterior cingulate gyrus and higher perfusion in the putamen, bilaterally. The latter association was independent from verbal working memory capacity. Moreover, anxiety symptomatology was associated with lower perfusion in the hippocampus (after controlling for verbal episodic memory difficulties). Associations between regional perfusion and psychoemotional scores were specific to depression or anxiety, respectively, and independent of the presence of visible lesions on conventional MRI. Results are discussed in relation to the role of specific limbic and paralimbic regions in the pathogenesis of symptoms of depression and anxiety.
Databáze: OpenAIRE
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