Preoperative Cyfra21-1 and SCC-Ag serum titers predict survival in patients with stage II esophageal squamous cell carcinoma
| Autor: | Xiao-Min Zheng, Yu-Jing Han, Gui-Rong Feng, Xun Cao, Juan Yang, Ruo-Yan Wang, Jun Li, Lin Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Esophageal Neoplasms Cyfra21-1 lcsh:Medicine Kaplan-Meier Estimate Preoperative care General Biochemistry Genetics and Molecular Biology Cytokeratin Antigen Antigens Neoplasm Esophageal squamous cell carcinoma Preoperative Care Carcinoma medicine Humans In patient Stage II Esophageal Squamous Cell Carcinoma Serpins Aged Neoplasm Staging Proportional Hazards Models Keratin-19 Medicine(all) SCC-Ag Proportional hazards model business.industry Biochemistry Genetics and Molecular Biology(all) Research lcsh:R General Medicine Middle Aged medicine.disease Prognosis Titer Multivariate Analysis Carcinoma Squamous Cell Female business |
| Zdroj: | Journal of Translational Medicine, Vol 10, Iss 1, p 197 (2012) Journal of Translational Medicine |
| ISSN: | 1479-5876 |
| Popis: | Background The purpose of this study is to evaluate the predictive significance of preoperative serum level of cytokeratin 19 fragments (Cyfra21-1) and squamous cell carcinoma antigen (SCC-Ag) after complete resection in patients with stage II esophageal squamous cell carcinoma (ESCC). Methods Between 1995 and 2006, a total of 379 patients in stage II ESCC who underwent complete resection were consecutively recruited. Statistical analyses were applied to test the associations between preoperative serum titers of Cyfra21-1 and SCC-Ag, clinicopathological factors and prognoses. Results Preoperative high and normal serum level of Cyfra21-1 and SCC-Ag were found in 47.8%, 52.2% and 72.8%, 27.2%, respectively. The 1-, 3-, 5-year overall survival rate for the entire cohort of patients was 95%, 78%, and 56%, respectively. Median overall survival (OS) was 45.3 months longer in patients with low preoperative serum level of Cyfra21-1 (91.9 months) than those with high preoperative serum level of Cyfra21-1 (46.6 months) (P Conclusions The preoperative serum level of Cyfra21-1 and SCC-Ag are independently significant predictors which negatively affected the survivals of patients with stage II ESCC. |
| Databáze: | OpenAIRE |
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