Survival Outcomes of Lung Transplant Recipients From Donors With Abnormal Kidney Function
| Autor: | S.Z. Shah, Basar Sareyyupoglu, Mathew Thomas, David B. Erasmus, Samuel Jacob, M.M. El-Sayed Ahmed, T. Jarmi, Ian A. Makey, Nan Zhang, Si M. Pham, Kevin Landolfo |
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| Rok vydání: | 2022 |
| Předmět: |
Pulmonary and Respiratory Medicine
Transplantation medicine.medical_specialty Lung business.industry Proportional hazards model Hazard ratio Renal function Gastroenterology Confidence interval medicine.anatomical_structure Internal medicine Medicine Surgery business Cardiology and Cardiovascular Medicine Donor pool Donor kidney Abnormal kidney function |
| Zdroj: | The Annals of Thoracic Surgery. |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/j.athoracsur.2022.10.016 |
| Popis: | Recovering lungs with pulmonary edema due to abnormal kidney function is considered one of the expanded selection criteria for lung transplant. The aim of this study is to assess lung transplant recipients' survival from donors with abnormal kidney function and to determine differences in lung recovery rates from donors with and donors without abnormal kidney function.We reviewed the United Network for Organ Sharing registry for first-time adult lung transplant donors and recipients from June 2005 to March 2017. Donor kidney function was categorized into three groups based on estimated glomerular filtration rate: group I, greater than 60 mL/min; group II, 15 to 59 mL/min; and group III, less than 15 mL/min. Recipient survival was stratified based on estimated glomerular filtration rate using Kaplan-Meier. A multivariate Cox Regression model with known risk factors that affect survival was used to compare survival among groups. Comparison of lung recovery among the three groups was also performed.Lung recovery rates were 29.7% (15,670 of 52,747), 19.4% (3879 of 20,040), and 18.1% (704 of 3898) for groups I, II, and III, respectively. The 1-, 3-, and 5-year recipient survival rates were 86.2%, 69.2%, and 55.7% for group I; 84.9%, 66.9%, and 53.8% for group II; and 85.5%, 65.3%, and 50.3% for group III, respectively (adjusted P = .25; multivariate Cox regression method). When group I was used as reference, the adjusted hazard ratio for group II was 1.04 (95% CI, 0.98-1.10) and for group III, it was 1.08 (95% CI, 0.96-1.23), after adjusting with the multivariate Cox regression model.There was no significant difference in lung recipient survival. The lung recovery rate from donors with abnormal kidney function was lower compared with that of donors with normal kidney function. |
| Databáze: | OpenAIRE |
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