High basal metabolic rate does not elevate oxidative stress during reproduction in laboratory mice
| Autor: | Aneta Książek, Marek Konarzewski, Łukasz Ołdakowski, Paweł Brzęk |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Physiology media_common.quotation_subject Aquatic Science medicine.disease_cause Kidney chemistry.chemical_compound Mice Blood serum Internal medicine Lactation medicine Animals Parental investment Molecular Biology Ecology Evolution Behavior and Systematics media_common biology Reproduction Malondialdehyde Catalase Oxidative Stress Endocrinology medicine.anatomical_structure chemistry Liver Insect Science Basal metabolic rate biology.protein Animal Science and Zoology Female Basal Metabolism Oxidative stress DNA Damage |
| Zdroj: | The Journal of experimental biology. 217(Pt 9) |
| ISSN: | 1477-9145 |
| Popis: | Summary Increased oxidative stress (OS) has been suggested as a physiological cost of reproduction. However, previous studies reported ambiguous results, with some even showing a reduction of oxidative damage during reproduction. We tested whether the link between reproduction and OS is mediated by basal metabolic rate (BMR), which has been hypothesised to affect both the rate of radical oxygen species production and anti-oxidative capacity. We studied the effect of reproduction on OS in females of laboratory mice divergently selected for high (H-BMR) and low (L-BMR) BMR, previously shown to differ with respect to parental investment. Non-reproducing L-BMR females showed higher oxidative damage to lipids (quantified as the level of malonaldehyde in internal organ tissues) and DNA (quantified as the level of 8-oxodG in blood serum) than H-BMR females. Reproduction did not affect oxidative damage to lipids in either line; however, it reduced damage to DNA in L-BMR females. Reproduction increased catalase activity in liver (significantly stronger in L-BMR females) and decreased in kidneys. We conclude that the effect of reproduction on OS depends on the initial variation in BMR and varies between studied internal organs and markers of OS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|