Tracking genomic cancer evolution for precision medicine: The Lung TRACERx Study

Autor:	Salli Muller, Karl S. Peggs, David A. Waller, Elza C de Bruin, Natasha Iles, Magali Taylor, Helen E. Davies, Leena Dennis Joseph, Matthew G Krebs, David Lawrence, Gerald Langman, Maggie Wilcox, Alan Hackshaw, Fiona H Blackhall, Jonathan Bennett, Mairead MacKenzie, Richard Booton, Haydn Adams, Seema Shafi, Daisuke Nonaka, Yenting Ngai, Sam M. Janes, Gary Middleton, Jacqueline A Shaw, Ged Brady, John Le Quesne, Ian Woolhouse, Mariam Jamal-Hanjani, Jason F. Lester, Iftekhar Khan, Tanya Ahmad, Mahendran Chetty, Martin Forster, Richard Mitter, Madhav Djearman, Charles Swanton, Joy Millar, Andrew Rowan, Sean W. Smith, Keith Buchan, A R Denison, Nicolai Juul Birkbak, Nik Matthews, Selvaraju Veeriah, Sergio A. Quezada, Dean A. Fennell, Hardy Remmen, Aengus Stuart, Catrin Pritchard, Nirupa Murugaesu, Malgorzata Kornaszewska, Elaine Smith, Siow Ming Lee, Nicholas McGranahan, Arrigo Capitano, Babu Naidu, Caroline Dive, Marianne Nicolson, Rajesh Shah, Richard Attanoos, Yvonne Summers, Bruno Morgan, Stuart Horswell, Mark Cobbold, Ben Wilcox, Keith M. Kerr, Tom Haswell, Philip A.J. Crosbie, Jacki Goldman, Max Salm, Mary Falzon
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Oncology Lung Neoplasms Colorectal cancer 03502 Genetics - General CHROMOSOMAL INSTABILITY Metastasis Prostate cancer Community Page Carcinoma Non-Small-Cell Lung PROGNOSTIC-SIGNIFICANCE Medicine and Health Sciences Pulmonary Medicine Longitudinal Studies Neoplasm Metastasis Biology (General) genes genetic analysis laboratory techniques genetic techniques 16006 Respiratory system - Pathology BREAST CANCERS General Neuroscience Genomics respiratory system PANCREATIC-CANCER Treatment Outcome Lung TRACERx Study Disease Progression General Agricultural and Biological Sciences medicine.medical_specialty QH301-705.5 Immunology BIOLOGY CLONAL SELECTION Biology Human Medicine Medical Sciences General Biochemistry Genetics and Molecular Biology Molecular Genetics Breast cancer SDG 3 - Good Health and Well-being Antigens Neoplasm Internal medicine Pancreatic cancer Genetics Biomarkers Tumor medicine Humans 10062 Biochemistry studies - Nucleic acids purines and pyrimidines Primates Mammalia Vertebrata Chordata Animalia (Animals Chordates Humans Mammals Primates Vertebrates) - Hominidae [86215] human common Lung cancer genomic study Clinical Genetics Evolutionary Biology Biochemistry and Molecular Biophysics General Immunology and Microbiology primary non-small cell lung cancer Carcinoma Non-Small-Cell Lung (MeSH) Lung Neoplasms (MeSH) respiratory system disease neoplastic disease MUTATIONAL EVOLUTION Biology and Life Sciences Cancer ADENOCARCINOMA functional heterogeneity SOMATIC MUTATIONS clonal heterogeneity Precision medicine medicine.disease intratumour genetic heterogeneity 24004 Neoplasms - Pathology clinical aspects and systemic effects respiratory tract diseases 03508 Genetics - Human Drug Resistance Neoplasm INTRATUMOR HETEROGENEITY Clinical Immunology somatic mutational heterogeneity BIOCHEMISTRY ACQUIRED-RESISTANCE
Zdroj:	Jamal-Hanjani, M, Hackshaw, A, Ngai, Y, Shaw, J, Dive, C, Quezada, S, Middleton, G, de Bruin, E, Le Quesne, J, Shafi, S, Falzon, M, Horswell, S, Blackhall, F, Khan, I, Janes, S, Nicolson, M, Lawrence, D, Forster, M, Fennell, D, Lee, S-M, Lester, J, Kerr, K, Muller, S, Iles, N, Smith, S, Murugaesu, N, Mitter, R, Salm, M, Stuart, A, Matthews, N, Adams, H, Ahmad, T, Attanoos, R, Bennett, J, Birkbak, N J, Booton, R, Brady, G, Buchan, K, Capitano, A, Chetty, M, Cobbold, M, Crosbie, P, Davies, H, Denison, A, Djearman, M, Goldman, J, Haswell, T, Joseph, L, Kornaszewska, M, Krebs, M, Langman, G, MacKenzie, M, Millar, J, Morgan, B, Naidu, B, Nonaka, D, Peggs, K, Pritchard, C, Remmen, H, Rowan, A, Shah, R, Smith, E, Summers, Y, Taylor, M, Veeriah, S, Waller, D, Wilcox, B, Wilcox, M, Woolhouse, I, McGranahan, N & Swanton, C 2014, ' Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study ', P L o S Biology, vol. 12, no. 7, e1001906 . https://doi.org/10.1371/journal.pbio.1001906 PLoS Biology, Vol 12, Iss 7, p e1001906 (2014) PLoS Biology
ISSN:	1544-9173
DOI:	10.1371/journal.pbio.1001906
Popis:	TRACERx, a prospective study of patients with primary non-small cell lung cancer, aims to map the genomic landscape of lung cancer by tracking clonal heterogeneity and tumour evolution from diagnosis to relapse. The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.
Databáze:	OpenAIRE
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