Fetal sex alters maternal anti-Mullerian hormone during pregnancy in cattle
| Autor: | Michael S. Neal, Timothy F. Carter, N. N. Costa, Flávio Vieira Meirelles, Daniel Gillis, Mayra Pauline Ribeiro Costa, W. Allan King, Tiago Henrique Câmara de Bem, Otávio Mitio Ohashi, Moysés dos Santos Miranda, Rodrigo de Morais, Anja Stojsin-Carter, Laura A. Favetta |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Anti-Mullerian Hormone Male endocrine system medicine.medical_specialty endocrine system diseases Placenta Biology 03 medical and health sciences 0302 clinical medicine Endocrinology Fetus Food Animals Pregnancy Fetal sex Internal medicine medicine Animals Maternal-Fetal Exchange 030219 obstetrics & reproductive medicine urogenital system Anti-Müllerian hormone General Medicine medicine.disease FETO 030104 developmental biology medicine.anatomical_structure embryonic structures biology.protein Gestation Pregnancy Animal Animal Science and Zoology Cattle Female AMH receptor hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Anti-Mullerian hormone (AMH) is expressed by both male and female fetuses during mammalian development, with males expressing AMH earlier and at significantly higher concentration. The aim of the current study was to explore the potential impact of pregnancy and fetal sex on maternal AMH and to determine if plasma (Pl) AMH or placenta intercotyledonary membrane and cotyledonary AMH receptor 2 (AMHR2) mRNA expression differ in pregnant cows carrying male vs. female fetuses. AMH levels in blood were measured using a bovine optimized ELISA kit. Cows pregnant with a male fetus were observed to have a significantly greater difference in Pl AMH between day 35 and 135 of gestation. Average fetal AMH level between 54 and 220days of gestation was also observed to be significantly higher in male vs. female fetuses. Intercotyledonary membranes and cotyledons were found to express AMHR2 between days 38 and 80 of gestation at similar levels in both fetal sexes. These findings support the hypothesis that fetal sex alters maternal Pl AMH during pregnancy in cattle. |
| Databáze: | OpenAIRE |
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