Little evidence for a chronotolerance effect for impulse noise exposure in the C57BL/6J mouse
| Autor: | Eric C. Bielefeld, Ryan T. Harrison |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Hearing loss Otoacoustic Emissions Spontaneous Audiology Impulse noise Mice 03 medical and health sciences 0302 clinical medicine Evoked Potentials Auditory Brain Stem otorhinolaryngologic diseases medicine Animals Circadian rhythm Cochlea Chronobiology Phenomena Absolute threshold of hearing business.industry General Neuroscience medicine.disease Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Auditory brainstem response Acoustic Stimulation Hearing Loss Noise-Induced Female Hair cell medicine.symptom Noise business 030217 neurology & neurosurgery Noise-induced hearing loss |
| Zdroj: | Neuroscience Letters. 684:127-131 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2018.07.028 |
| Popis: | Noise-induced hearing loss affects a large number of adults and children worldwide, and continues to be a major public health problem. The cochlea is an organ that maintains delicate metabolic homeostasis and precise mechanical architecture. Disruption of either can cause temporary or permanent injury. Impulse noises, which are short-duration, high-level bursts of sound caused by explosions, such as gunfire, can injure the cochlea through combinations of mechanical and metabolic injury. Susceptibility to the metabolic component of noise injury may vary with the circadian rhythm, a phenomenon known as chronotolerance. Chronotolerance to noise injury has been demonstrated for a one-hour noise exposure at a fixed level, but chronotolerance for impulse noise-induced hearing loss has never been studied. Forty-four mice were exposed to 500 short-duration clicks at 137 dB peSPL at one of four hours after light onset: 2, 8, 14, or 20. Auditory brainstem response threshold shifts were measured at 3, 7, and 21 days after the exposure to measure hearing loss, and post mortem outer hair cell counts were used to confirm cochlear injury. The testing revealed no significant differences between the four exposure times for hearing threshold shifts, but did detect a small, but statistically significant, difference in outer hair cell loss, in which the loss was greatest for the mice exposed two hours after light offset. Therefore, a weak chronotolerance effect for impulse noise was detected, though the functional significance of the effect is low. Further investigation is required to more fully understand the relationship between circadian rhythm and hearing loss from different types of noise exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect