Targeting Hyaluronan Interactions in Spinal Cord Astrocytomas and Diffuse Pontine Gliomas
| Autor: | Mark G. Slomiany, Anthony P. Leonard, Bernard L. Maria, John T. Lucas, Anne G. Gilg, May Abdel-Wahab, Bryan P. Toole, William G. Wheeler, Lauren B. Tolliver, Michael A. Babcock, Nalin Gupta |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Central nervous system Brain Stem Neoplasm Spinal Cord Neoplasm Biology Astrocytoma Article chemistry.chemical_compound Glioma Hyaluronic acid medicine ATP Binding Cassette Transporter Subfamily G Member 2 Animals Brain Stem Neoplasms Humans Spinal Cord Neoplasms Hyaluronic Acid Child neoplasms Medulloblastoma medicine.disease Spinal cord nervous system diseases Neoplasm Proteins Rats Disease Models Animal medicine.anatomical_structure Hyaluronan Receptors chemistry Drug Resistance Neoplasm Pediatrics Perinatology and Child Health Basigin ATP-Binding Cassette Transporters Neurology (clinical) |
| Popis: | Although significant advances have been made in treating malignant pediatric central nervous system tumors such as medulloblastoma, no effective therapy exists for diffuse pontine glioma or intramedullary spinal astrocytoma. Biology of these 2 tumors is poorly understood, in part because diffuse pontine gliomas are not treated surgically, and tumor specimens from intramedullary spinal astrocytomas are rare and minuscule. At the 2007 Neurobiology of Disease in Children Symposium, we presented evidence that malignant glioma behaviors, including antiapoptosis, invasiveness, and treatment resistance, are enhanced by hyaluronan, an extracellular glycosaminoglycan. We review the clinical course of pediatric intramedullary spinal astrocytoma and diffuse pontine glioma, and show expression of membrane proteins that interact with hyaluronan: CD44, extracellular matrix metalloproteinase inducer, and breast cancer resistance protein (BCRP/ABCG2). Furthermore, we describe novel animal models of these tumors for preclinical studies. These findings suggest that hyaluronan antagonism has potential therapeutic value in malignant central nervous system tumors. |
| Databáze: | OpenAIRE |
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