Soluble Intercellular Adhesion Molecule-1 (sICAM-1) as a Biomarker of Vascular Cognitive Impairment in Older Adults
| Autor: | Israel Grijalva-Otero, Lourdes Basurto Acevedo, Sara Vega García, Juan Cuadros-Moreno, Rosalinda Sánchez-Arenas, Jose Guerrero Cantera, Michael A. Gregory, Laura Alejandra Mejía Alonso, Sergio Martínez Gallardo, Antonio Villa Romero, Leticia Manuel-Apolinar, Jaime de Jesús Iuit Rivera, Sergio Sánchez-García, Juana Angélica Garcia Dominguez, Paola Garcia de la Torre |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Cognitive Neuroscience Frail Elderly Neuroimaging Neuropsychological Tests Gastroenterology 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine Medicine Aging brain Humans Cognitive Dysfunction Endothelial dysfunction Pathological Mexico Aged Aged 80 and over ICAM-1 030214 geriatrics business.industry Dementia Vascular Neuropsychology medicine.disease Intercellular Adhesion Molecule-1 Up-Regulation stomatognathic diseases Psychiatry and Mental health Socioeconomic Factors Sarcopenia Case-Control Studies Cohort Biomarker (medicine) Female Independent Living Geriatrics and Gerontology business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Dementia and geriatric cognitive disorders. 47(4-6) |
| ISSN: | 1421-9824 |
| Popis: | Background: Endothelial dysfunction and subsequent inflammation contribute to the development of vascular cognitive impairment (VCI). Soluble intercellular adhesion molecule-1 (sICAM-1) is upregulated in endothelial dysfunction and promotes an inflammatory response; however, the relationship between sICAM-1 and VCI remains equivocal. Objective: To determine whether sICAM-1 contributes to the prediction of VCI. Methods: Community-dwelling older adults (n = 172) from the “Cohort of Obesity, Sarcopenia and Frailty of Older Mexican Adults” (COSFOMA) study were identified as VCI or controls using standard neuropsychological evaluations and neuroimaging. sICAM-1 was quantified using ELISA, and multivariate logistic regression determined the association between sICAM-1 and VCI. Results: A total of 31 VCI cases were identified. sICAM-1 was higher in VCI (VCI: 450.7 [241.6] ng/mL vs. controls: 296.9 [140.9] ng/mL). sICAM-1 concentrations above the 90th percentile (464.1 ng/mL) were associated with VCI group membership in all models (OR: 6.9, 95% CI: 1.1–42.2). The final saturated model explained 64% of the variance in VCI group membership. Conclusion: High concentrations of sICAM-1 are independently associated with VCI group membership. Efforts to further characterize the relationship between indices of endothelial dysfunction and pathological changes to the aging brain should be further pursued. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|