No Evidence of Association between NOD2/CARD15 Gene Polymorphism and Atherosclerotic Events after Renal Transplantation

Autor: Anne Duperrier, Cécile Courivaud, Didier Ducloux, Philippe Saas, Christophe Ferrand, Pierre Tiberghien, Marina Deschamps, Jean-Marc Chalopin
Přispěvatelé: Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Service d'urologie, andrologie et transplantation rénale, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques, Plateforme de Biomonitoring, Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), This study is supported by grants from the Fondation Transplantation. CC received financial support from the Fondation transplantation (#ET-050320). MD received financial support from the Comité Départemental de la Ligue contre le Cancer du Jura., Saas, Philippe, Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC)
Rok vydání: 2006
Předmět:
Adult
Male
[SDV.IMM] Life Sciences [q-bio]/Immunology
Nod2 Signaling Adaptor Protein
Single-nucleotide polymorphism
030204 cardiovascular system & hematology
Biology
Polymorphism
Single Nucleotide
Article
MESH: Atherosclerosis
MESH: Kidney Transplantation
Pathogenesis
03 medical and health sciences
0302 clinical medicine
MESH: Intracellular Signaling Peptides and Proteins
Genotype
medicine
Humans
MESH: Nod2 Signaling Adaptor Protein
SNP
innate immunity
Kidney transplantation
030304 developmental biology
0303 health sciences
Transplantation
Kidney
MESH: Humans
MESH: Middle Aged
MESH: Polymorphism
Single Nucleotide
Intracellular Signaling Peptides and Proteins
MESH: Adult
MESH: Toll-Like Receptor 4
Middle Aged
medicine.disease
Kidney Transplantation
MESH: Male
digestive system diseases
Toll-Like Receptor 4
medicine.anatomical_structure
inflammation
Immunology
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
Gene polymorphism
atherosclerosis
MESH: Female
Zdroj: Transplantation
Transplantation, Lippincott, Williams & Wilkins, 2006, 81 (8), pp.1212-5. ⟨10.1097/01.tp.0000202846.17619.a4⟩
ISSN: 0041-1337
1534-6080
DOI: 10.1097/01.tp.0000202846.17619.a4
Popis: International audience; Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated levels of C-reactive protein and by a correlation between posttransplant AE and Toll-like receptor-4 Asp299Gly polymorphism. Here, we analyze the influence NOD2/CARD15 gene polymorphism since NOD2 can modulate macrophage pro-inflammatory activity and macrophage is present in early atherosclerotic lesions. The incidence of single nucleotide polymorphism (SNP) in the three major polymorphic region of NOD2 gene (SNP8, SNP12 and SNP13) was assessed in 182 RTR and the correlation between such polymorphism and the development of AE was analyzed. No correlation was observed between NOD2 gene polymorphism and the occurrence of AE after renal transplantation. NOD2 gene polymorphism thus does not appear to influence cardiovascular complications in RTR.
Databáze: OpenAIRE
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