Effects of corn oil and benzyl acetate on number and size of azaserine-induced foci in the pancreas of LEW and F344 rats
| Autor: | Charles I. Coon, Thomas J. Curphey, Denise L. MacMillan, Daniel S. Longnecker, Evelyne F. Lhoste, B. D. Roebuck |
|---|---|
| Přispěvatelé: | Department of Pathology, Lower Saxony State Office for Consumer Protection and Food Safety, Department of Pharmacology and Toxicology, University of Utah |
| Jazyk: | angličtina |
| Rok vydání: | 1986 |
| Předmět: |
Male
Health Toxicology and Mutagenesis [SDV]Life Sciences [q-bio] digestive system 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology 0302 clinical medicine Species Specificity Benzyl Compounds Acinar cell medicine Animals Plant Oils Azaserine Carcinogen Public Health Environmental and Occupational Health Histology 04 agricultural and veterinary sciences 040401 food science Molecular biology Rats Inbred F344 Rats Benzyl acetate Pancreatic Neoplasms Disease Models Animal medicine.anatomical_structure chemistry Biochemistry Rats Inbred Lew 030220 oncology & carcinogenesis Corn Oil Pancreas Corn oil Research Article Endocrine gland medicine.drug |
| Zdroj: | Environmental Health Perspectives Environmental Health Perspectives, National Institute of Environmental Health Sciences, 1986, 68, pp.197. ⟨10.2307/3430264⟩ |
| ISSN: | 0091-6765 1552-9924 |
| DOI: | 10.2307/3430264⟩ |
| Popis: | The response of LEW and F344 strain rats to the pancreatic carcinogen azaserine was compared using the size and number of azaserine-induced acidophilic acinar cell foci and nodules as parameters in a 4-month experiment. A second experiment compared the effect of corn oil intake by gavage and dietary routes on the growth of azaserine-induced pancreatic lesions in LEW rats. A third experiment tested the activity of benzyl acetate in regard to its ability to induce acinar cell foci or to promote the growth of such foci in azaserine-treated rats. The results showed that equivalent doses of azaserine induce two to seven times more foci in LEW than in F344 rats, and that LEW rats have a higher incidence of "spontaneous" foci than F344 rats. Azaserine-treated LEW rats that were given 5 mL corn oil/kg body weight 5 days per week by gavage developed more acinar cell foci than rats fed a basal diet (chow). Addition of an equivalent amount of corn oil to chow had a similar effect of enhancing the development of foci. Rats of neither strain developed acinar cell foci when benzyl acetate was given by gavage or in the diet nor was there evidence that benzyl acetate has a significant effect on the development of foci in azaserine-treated rats. These studies also demonstrate that the azaserine/rat model of pancreatic carcinogenesis which was developed in LEW rats can be adapted for use with F344 rats. |
| Databáze: | OpenAIRE |
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