Percutaneous penetration and dermal exposure risk assessment of chlorinated paraffins
| Autor: | Yawei Wang, Yongfeng Lin, Wei Gao, Guibin Jiang, Yingjun Wang, Lu Jiang, Yong Liang |
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| Rok vydání: | 2021 |
| Předmět: |
China
Environmental Engineering Health Toxicology and Mutagenesis 0211 other engineering and technologies 02 engineering and technology 010501 environmental sciences Percutaneous penetration complex mixtures 01 natural sciences Dermal exposure Risk Assessment In vitro model stomatognathic system Chlorinated paraffins Hydrocarbons Chlorinated Environmental Chemistry Humans Waste Management and Disposal 0105 earth and related environmental sciences 021110 strategic defence & security studies Chromatography Chemistry Water Permeability coefficient Pollution carbohydrates (lipids) stomatognathic diseases Paraffin Skin penetration Environmental Monitoring |
| Zdroj: | Journal of hazardous materials. 416 |
| ISSN: | 1873-3336 |
| Popis: | The widespread occurrence of chlorinated paraffins (CPs) in environmental matrices has resulted in a high frequency exposure to CPs via dermal contact. To quantitatively estimate percutaneous penetration of CPs, Episkin® human skin equivalents (HSE) was applied as an in vitro model to evaluate the mechanism of percutaneous penetration of CPs. The co-exposure of CPs mixtures to HSE showed that about 11.7% and 10.2% of short-chain CPs (SCCPs) and medium-chain CPs (MCCPs) could penetrate the HSE and enter the receptor fluid, while no long-chain CPs (LCCPs) (C>17) were able to penetrate the HSE during the 36-h assay period. The experimentally obtained permeability coefficient (Kp) values for CPs were significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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