Homology modeling in drug discovery: current trends and applications
| Autor: | Sharangdhar S. Phatak, Claudio N. Cavasotto |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Drug discovery Computer science In silico Molecular Sequence Data Nanotechnology Data science Protein Structure Secondary Structural genomics Structural homology Models Chemical Pharmaceutical technology Structural Homology Protein Prediction methods Drug Discovery Animals Humans Amino Acid Sequence Homology modeling |
| Zdroj: | Drug Discovery Today. 14:676-683 |
| ISSN: | 1359-6446 |
| Popis: | As structural genomics (SG) projects continue to deposit representative 3D structures of proteins, homology modeling methods will play an increasing role in structure-based drug discovery. Although computational structure prediction methods provide a cost-effective alternative in the absence of experimental structures, developing accurate enough models still remains a big challenge. In this contribution, we report the current developments in this field, discuss in silico modeling limitations, and review the successful application of this technique to different stages of the drug discovery process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect