Inhibition of the Plasminogen Activator Urokinase by Alpha-Tocopherol
| Autor: | D. Ogston |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Vitamin K
medicine.medical_treatment Fibrin Plasma Plasminogen Activators chemistry.chemical_compound Phytol Menadione medicine Animals Humans Vitamin E Protease Inhibitors Bovine serum albumin Urokinase biology Chemistry Fibrinolysis Serum Albumin Bovine Hematology General Medicine Urokinase-Type Plasminogen Activator Molecular biology Hydroquinones Plasminogen Inactivators Biochemistry biology.protein Cattle alpha-Tocopherol Oligopeptides Plasminogen activator medicine.drug |
| Zdroj: | Acta Haematologica. 67:114-118 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000207036 |
| Popis: | alpha-Tocopherol (vitamin E) inhibited the activity of urokinase on fibrin plates and on the amidolytic substrate S-2444 in a concentration- and time-dependent manner. Inhibition was not removed by dialysis. In the presence of dilutions of plasma, protein-containing fractions of gel-filtered plasma, or bovine serum albumin, the inhibition of urokinase by alpha-tocopherol was abolished. Urokinase activity was not inhibited by phytol, menadione or hydroquinone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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