The utility of hyperbaric oxygen therapy in post-transplant cyclophosphamide-induced hemorrhagic cystitis: a case report and review of the literature

Autor:	Hana Safah, Nakhle S. Saba, Francisco Socola, Keith Van Meter, Kshama Bhyravabhotla, Basil Khalaf, Moayed Ibrahim
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Adult Male medicine.medical_specialty Cyclophosphamide Post transplant cyclophosphamide medicine.medical_treatment Graft vs Host Disease lcsh:Medicine Cystectomy 03 medical and health sciences 0302 clinical medicine Hyperbaric oxygen Post-transplant Surgical oncology Cystitis Hemorrhagic cystitis Case report medicine Humans Child Hyperbaric Oxygenation Acute myeloid leukemia business.industry lcsh:R Hematopoietic Stem Cell Transplantation General Medicine Middle Aged Graft-versus-host disease prophylaxis medicine.disease Alternative treatment Surgery surgical procedures operative 030220 oncology & carcinogenesis Stem cell business 030215 immunology medicine.drug
Zdroj:	Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-4 (2021) Journal of Medical Case Reports
ISSN:	1752-1947
Popis:	BackgroundTo date, there are only a few case reports of cyclophosphamide (Cy)-induced hemorrhagic cystitis (HC) in adult or pediatric allogeneic stem cell transplant (SCT) patients treated successfully with hyperbaric oxygen (HBO). In all the reported cases, Cy was used as a part of the conditioning regimen, rather than post-transplant for graft-versus-host-disease (GVHD) prophylaxis. More recently, the risk of HC in allogeneic SCT is further increased by the widespread use of post-transplantation cyclophosphamide (PTCy) as a highly effective strategy for GVHD prophylaxis. This is the first case reported of PTCy-induced HC successfully treated with HBO to the best of our knowledge.Case presentationIn this article, we present a 58-year-old Caucasian male case of allogeneic SCT complicated by severe HC following PTCy, which was successfully treated with HBO, eliminating the need for cystectomy.ConclusionHBO can be a safe, noninvasive, alternative treatment modality for PTCy-induced HC developing in allogeneic SCT patients.
Databáze:	OpenAIRE
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