Radio-Pathological Correlations in Patients with Liver Metastases for Colorectal Cancer
| Autor: | Daniel Azoulay, Luis Sarría, Luis Tejedor, Alejandro Serrablo, Leyre Serrablo, Carlos Paradisi, Panagiotis Paliogiannis, Carlos Horndler |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Necrosis Hepatic resection Colorectal cancer Gastroenterology Fibrosis Internal medicine medicine Hepatectomy Humans In patient Gastrointestinal cancer Pathological Aged Retrospective Studies business.industry Liver Neoplasms Retrospective cohort study Middle Aged medicine.disease Tumor Burden Female Surgery medicine.symptom Colorectal Neoplasms Tomography X-Ray Computed business |
| Zdroj: | Digestive Surgery. 37:383-389 |
| ISSN: | 1421-9883 0253-4886 |
| DOI: | 10.1159/000506105 |
| Popis: | Background:Colorectal cancer (CRC) is the most frequent gastrointestinal cancer. The liver is the organ most commonly affected by CRC metastases. Synchronous CRC liver metastases (CRCLM) are present in 15–25% at diagnosis, and metastases are confined to the liver in 70–80% of these cases. The aim of the present study was to investigate the existence of significant correlations between the pathological features and computed tomography scan morpho-densitometric findings. Summary:A retrospective study of prospectively collected data has been performed; all patients underwent curative-intent hepatic resection from January 2004 to December 2012 and had histologically confirmed CRCLM. Key Messages: Thirty-four (57%) patients were males; the mean age was 64.4 (±10.2) years. Statistically significant differences have been found with the percentages of intra-tumoral fibrosis (p = 0.038) and necrosis (p = 0.007); the values of fibrosis are higher in the absence of a peri-lesional ring, while those of necrosis are higher in the presence of a peri-lesional ring.There was a correlation between the histopathological response to treatments and the global attenuation levels observed in the computed tomography scan of CRCLM. Furthermore, the presence of a radiologically evidenced peripheral ring was associated with the amount of viable tumor cells in the periphery of the tumor, and with responses predominated by necrosis. More studies are needed to clarify the radiological and histological correlation and to be able to better select patients who are going to undergo surgery. |
| Databáze: | OpenAIRE |
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