Psorachromene induces apoptosis and suppresses tumor growth in NSCLC cells harboring EGFR L858R / T790M / C797S

Autor:	Tong‐Hong Wang, Yann‐Lii Leu, Chin‐Chuan Chen, Hsin‐Jung Li, Shuenn‐Chen Yang, Kuo‐Yen Huang, Chi‐Yuan Chen
Rok vydání:	2022
Předmět:	Pharmacology Lung Neoplasms Mice Nude Antineoplastic Agents Apoptosis ErbB Receptors Molecular Docking Simulation Mice Carcinoma Non-Small-Cell Lung Cell Line Tumor Mutation Animals Humans Protein Kinase Inhibitors
Zdroj:	Phytotherapy Research. 36:2116-2126
ISSN:	1099-1573 0951-418X
DOI:	10.1002/ptr.7432
Popis:	The extracts from Psoralea corylifolia Linn. (P. corylifolia) seeds have been shown to display antitumor activity. To date, the prospects of this plant and its active compounds in the treatment of non-small-cell lung cancer (NSCLC) have not been thoroughly studied. In this study, we identified a novel psorachromene compound that displays selective cytotoxic effects on all NSCLC cells tested, including NSCLC cells harboring epidermal growth factor receptor (EGFR) activation mutants (H1975
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a779cf3d238968a4608eb68fd082bfbd https://doi.org/10.1002/ptr.7432 Zobrazit plný text záznamu Plný text