Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice
| Autor: | Ikuo Kato, Minglun Tsai, Koji Ataka, Akio Inui, Akihiro Asakawa, Miharu Ushikai, Kaori Atsuchi, Ken-Ichiro Koyama, Yuki Sato, Mineko Fujimiya |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Ratón Motility Nerve Tissue Proteins Biology Mice Calcium-binding protein Internal medicine medicine Animals Nucleobindins Gastroduodenal motility Antrum Injections Intraventricular General Neuroscience Calcium-Binding Proteins digestive oral and skin physiology Feeding Behavior Nucleobindin 2 DNA-Binding Proteins Mice Inbred C57BL Endocrinology Hypothalamus Anorectic Female Gastrointestinal Motility |
| Zdroj: | NeuroReport. 21:1008-1011 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/wnr.0b013e32833f7b96 |
| Popis: | Nesfatin-1 was recently identified as a peptide with anorexigenic effects that is localized in the hypothalamus and adipocytes. Not much is known about the effect of nesfatin-1 on gut motility. Food intake was measured after intracerebroventricular administration of nesfatin-1 in food-deprived mice. Antral and duodenal motility was assessed by using a manometric method in conscious fed mice. We found that centrally administered nesfatin-1 decreased food intake and inhibited gastroduodenal motility in mice. These results suggest that nesfatin-1 influences gut motility and feeding behaviour. |
| Databáze: | OpenAIRE |
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