Giant hepatocellular carcinoma with bone metastasis in a young adult, emerged from pigmented adenoma with beta-Catenin activation: A case report
| Autor: | Paula Döring, Lars Ivo Partecke, Sebastian Lünse, Claus-Dieter Heidecke |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Beta-catenin Hepatocellular carcinoma medicine.medical_treatment Case Report Malignant transformation 03 medical and health sciences 0302 clinical medicine Medicine Young adult biology business.industry Bone metastasis Hepatobiliary surgery Hepatocellular adenoma medicine.disease Rib resection digestive system diseases 030220 oncology & carcinogenesis biology.protein 030211 gastroenterology & hepatology Surgery Hepatectomy business |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| DOI: | 10.1016/j.ijscr.2017.04.001 |
| Popis: | Highlights • Hepatocellular carcinoma (HCC) is an extremely rare finding in young adult. • Giant HCCs are larger than 10 cm in diameter and mostly develop in non-cirrhotic livers. • Pigmented hepatocellular adenoma (HCA) with beta-catenin activation have an increased risk for malignant transformation. • Surgical resection is the only curative treatment with best long-term outcome. • Molecular classification of HCAs is a useful tool for risk assessment of malignant transformation. Introduction Hepatocellular carcinomas (HCC) that are very large in size are a very rare finding in young adult. The malignant transformation of a pigmented hepatocellular adenoma (HCA) with beta-Catenin activation is a possible cause for appearance of HCC. Presentation of case We present the case of a 33-year-old male with a huge HCC with bone metastasis, emerged from pigmented HCA with beta-Catenin activation. As a two-stage surgical procedure, a left hepatectomy followed by a partial rib resection was performed. Discussion Giant hepatocellular carcinomas mostly develop in non-cirrhotic livers and at time of diagnosis an extrahepatic spread occurs in up to 15%. In the present case, the progression from a benign HCA to malignant HCC was documented, as a unique finding. Surgical resection is the only curative treatment and was successfully performed in this case. Conclusion Hepatobiliary surgery with resection of metastases is the treatment with best long-term survival for patients with huge HCC. Molecular characterization as well as pigmentation analysis is useful tools for risk assessment of HCA. |
| Databáze: | OpenAIRE |
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