Do Medications Commonly Prescribed to Patients with Peripheral Arterial Disease Have an Effect on Nutritional Status? A Review of the Literature
| Autor: | J. Ian Spark, Christopher L. Delaney, Renee Fenton, Michelle Miller, Laura Brook-Barclay |
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| Rok vydání: | 2015 |
| Předmět: |
Drug
medicine.medical_specialty media_common.quotation_subject MEDLINE Alternative medicine Nutritional Status Disease 030204 cardiovascular system & hematology 03 medical and health sciences Peripheral Arterial Disease 0302 clinical medicine Risk Factors medicine Humans Hypoglycemic Agents 030212 general & internal medicine Vitamin B12 Intensive care medicine media_common Hypolipidemic Agents Polypharmacy business.industry Cardiovascular Agents General Medicine Surgery Cardiovascular agent Platelet aggregation inhibitor Cardiology and Cardiovascular Medicine business Deficiency Diseases Biomarkers Platelet Aggregation Inhibitors |
| Zdroj: | Annals of vascular surgery. 32 |
| ISSN: | 1615-5947 |
| Popis: | Background Polypharmacy is common among patients with peripheral arterial disease (PAD) with a combination of medications used for risk-factor modification and medical management of the disease itself. Interaction between commonly prescribed medications and nutritional status has not previously been well described. This review aims to critically appraise evidence exploring associations between medications commonly prescribed to patients with PAD and nutritional status and provide recommendations for practice. Methods A comprehensive literature search was conducted to locate studies relating to nutrient interactions among lipid-lowering, antihypertensive, antiplatelet, and oral hypoglycemic drug classes. Quality of the evidence was rated on the basis of recommendations by the National Health and Medical Research Council. Results A total of 25 articles were identified as suitable and included in the review. No studies were specific to patients with PAD, and hence findings highlighting risk of ubiquinone (coenzyme Q10 [CoQ10]) depletion with lipid-lowering medications, zinc depletion with antihypertensive medications, and vitamin B12 depletion with oral hypoglycemic medications are extrapolated from heterogeneous groups of patients and healthy adults. The body of evidence ranged in quality from satisfactory to poor. Conclusions High-quality research is required to confirm the interactions suggested by the included studies in patients with PAD specifically. It is, however, recommended that patients with PAD that are long-term consumers of the selected medications are monitored for CoQ10, zinc, and vitamin B12 to facilitate early identification of deficiencies and initiation of treatment. Treatment may involve dietary intervention and/or supplementation. |
| Databáze: | OpenAIRE |
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