Optimal normal tissue sparing in craniospinal axis irradiation using IMRT with daily intrafractionally modulated junction(s)
Autor: | Martina Kunze-Busch, J.M.A.M. Kusters, Johannes H.A.M. Kaanders, Peter van Kollenburg, Corrie Gidding, Geert O. Janssens, Rob J.W. Louwe, Erik J. van Lindert |
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Rok vydání: | 2010 |
Předmět: |
Organs at Risk
Cancer Research Age-related aspects of cancer [ONCOL 2] Supine position Adolescent medicine.medical_treatment Planning target volume Thyroid Gland Aetiology screening and detection [ONCOL 5] Craniospinal Irradiation Young Adult Esophagus Translational research [ONCOL 3] Perception and Action [DCN 1] otorhinolaryngologic diseases medicine Humans Radiology Nuclear Medicine and imaging Irradiation Cerebellar Neoplasms Child Radiation Injuries Radiation business.industry Radiotherapy Planning Computer-Assisted Stomach Heart Normal tissue sparing Spine Radiation therapy Intestines stomatognathic diseases Atlanto-Occipital Joint Oncology Child Preschool Dose reduction Dose Fractionation Radiation Esophagogastric Junction Radiotherapy Intensity-Modulated Cranial Irradiation business Nuclear medicine Craniospinal Medulloblastoma |
Zdroj: | International Journal of Radiation Oncology, Biology, Physics, 81, 1405-14 International Journal of Radiation Oncology, Biology, Physics, 81, 5, pp. 1405-14 |
ISSN: | 1879-355X 0360-3016 |
Popis: | Item does not contain fulltext PURPOSE: To develop a treatment technique for craniospinal irradiation using intensity-modulated radiotherapy (IMRT) with improved dose homogeneity at the field junction(s), increased target volume conformity, and minimized dose to the organs at risk (OARs). METHODS AND MATERIALS: Five patients with high-risk medulloblastoma underwent CT simulation in supine position. For each patient, an IMRT plan with daily intrafractionally modulated junction(s) was generated, as well as a treatment plan based on conventional three-dimensional planning (3DCRT). A dose of 39.6 Gy in 22 daily fractions of 1.8 Gy was prescribed. Dose-volume parameters for target volumes and OARs were compared for the two techniques. RESULTS: The maximum dose with IMRT was 107) were |
Databáze: | OpenAIRE |
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