Optimal normal tissue sparing in craniospinal axis irradiation using IMRT with daily intrafractionally modulated junction(s)

Autor: Martina Kunze-Busch, J.M.A.M. Kusters, Johannes H.A.M. Kaanders, Peter van Kollenburg, Corrie Gidding, Geert O. Janssens, Rob J.W. Louwe, Erik J. van Lindert
Rok vydání: 2010
Předmět:
Organs at Risk
Cancer Research
Age-related aspects of cancer [ONCOL 2]
Supine position
Adolescent
medicine.medical_treatment
Planning target volume
Thyroid Gland
Aetiology
screening and detection [ONCOL 5]
Craniospinal Irradiation
Young Adult
Esophagus
Translational research [ONCOL 3]
Perception and Action [DCN 1]
otorhinolaryngologic diseases
medicine
Humans
Radiology
Nuclear Medicine and imaging
Irradiation
Cerebellar Neoplasms
Child
Radiation Injuries
Radiation
business.industry
Radiotherapy Planning
Computer-Assisted
Stomach
Heart
Normal tissue sparing
Spine
Radiation therapy
Intestines
stomatognathic diseases
Atlanto-Occipital Joint
Oncology
Child
Preschool
Dose reduction
Dose Fractionation
Radiation
Esophagogastric Junction
Radiotherapy
Intensity-Modulated
Cranial Irradiation
business
Nuclear medicine
Craniospinal
Medulloblastoma
Zdroj: International Journal of Radiation Oncology, Biology, Physics, 81, 1405-14
International Journal of Radiation Oncology, Biology, Physics, 81, 5, pp. 1405-14
ISSN: 1879-355X
0360-3016
Popis: Item does not contain fulltext PURPOSE: To develop a treatment technique for craniospinal irradiation using intensity-modulated radiotherapy (IMRT) with improved dose homogeneity at the field junction(s), increased target volume conformity, and minimized dose to the organs at risk (OARs). METHODS AND MATERIALS: Five patients with high-risk medulloblastoma underwent CT simulation in supine position. For each patient, an IMRT plan with daily intrafractionally modulated junction(s) was generated, as well as a treatment plan based on conventional three-dimensional planning (3DCRT). A dose of 39.6 Gy in 22 daily fractions of 1.8 Gy was prescribed. Dose-volume parameters for target volumes and OARs were compared for the two techniques. RESULTS: The maximum dose with IMRT was 107) were
Databáze: OpenAIRE
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