Pentoxifylline Reduces Nephrotoxicity Associated With Cyclosporine In The Rat By Its Rheological Properties
| Autor: | S. B. Sanchez, M. de las Heras, L. E. Albornoz, Ricardo Mastai, G. Canteros, Juan Carlos Bandi |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Mean arterial pressure medicine.medical_specialty Vasodilator Agents Blood viscosity Hemodynamics Renal function Blood Pressure Kidney Nephrotoxicity Internal medicine Animals Medicine Erythrocyte deformability Pentoxifylline Transplantation business.industry Arteries Blood Viscosity Rats Endocrinology Vasoconstriction Renal blood flow Cyclosporine Kidney Diseases medicine.symptom Rheology business |
| Zdroj: | Transplantation. 64:1404-1407 |
| ISSN: | 0041-1337 |
| Popis: | BACKGROUND: The goals of this study were to evaluate whether administration of pentoxifylline (POF) reduces the nephrotoxicity associated with cyclosporine (CsA) in the rat, and whether the effect of POF is related to its rheological properties. METHODS: Mean arterial pressure was measured by an intraarterial catheter. Glomerular filtration rate and renal plasma flow were determined by measuring inulin and para-aminohippurate clearances, after double-blind coadministration for 10 days of CsA (25 mg/kg/day) with either vehicle or POF (45 mg/kg every 12 hr). These results were compared with those obtained in control rats. Blood viscosity and erythrocyte deformability were also evaluated after treatment using a cone plate viscometer and a filtration method, respectively. RESULTS: No changes were observed in mean arterial pressure in both groups compared with controls. Glomerular filtration rate was significantly lower in CsA-treated rats (0.3+/-0.1 ml/min/100 g) than in control animals (0.6+/-0.1 ml/min/100 g, P |
| Databáze: | OpenAIRE |
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