Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies
| Autor: | Pavel Piler, Michal Oravec, Pavel Odráška, Jan Kuta, Stanislav Synek, Lenka Dolezalova, Luděk Bláha |
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| Rok vydání: | 2013 |
| Předmět: |
Health
Toxicology and Mutagenesis Antineoplastic Agents Toxicology Chemical exposure Tandem Mass Spectrometry Occupational Exposure Humans Medicine Hospital pharmacy Sample extraction Workplace Cyclophosphamide Inductively coupled plasma mass spectrometry Chromatography High Pressure Liquid Czech Republic Platinum General Environmental Science business.industry Public Health Environmental and Occupational Health Contamination Monitoring data Antineoplastic Drugs Equipment Contamination Pharmacy Service Hospital business |
| Zdroj: | Archives of Environmental & Occupational Health. 69:148-158 |
| ISSN: | 2154-4700 1933-8244 |
| DOI: | 10.1080/19338244.2013.763757 |
| Popis: | This study investigates the surface contamination levels of cyclophosphamide and platinum (a marker of platinum-containing drugs) in storage and preparation areas of hospital pharmacies and their relationship to working conditions surveyed by questionnaire. In total, 259 wipe samples were collected in 13 hospital pharmacies over 4 sampling campaigns. After sample extraction with acetate buffer, cyclophosphamide and platinum were determined using high-performance liquid chromatography-tandem mass spectroscopy (HPLC-MS/MS) and inductively coupled plasma mass spectrometry (ICP-MS). Depending on the sampling spot and campaign, median concentrations ranged from2 to 61 pg/cm(2) and from0.2 to 6.9 pg/cm(2) for cyclophosphamide and platinum, respectively. Statistical evaluation of monitoring data revealed that the contamination level was significantly influenced by laboratory throughput (expressed as number of chemotherapies prepared per week), personnel expertise (ie, participation of pharmacists with academic education in drug admixture activities), and surface material. |
| Databáze: | OpenAIRE |
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