Radiocalcium absorption is reduced in postmenopausal women with vertebral and most types of peripheral fractures

Autor: Peter D. O’Loughlin, B. E. Christopher Nordin, Howard A. Morris, Michael Horowitz, Allan G. Need
Přispěvatelé: Morris, Howard, Nordin, B.E.Christopher, O'Loughlin, Peter, Need, Allan G, Horowitz, M
Rok vydání: 2003
Předmět:
Zdroj: Osteoporosis International. 15:27-31
ISSN: 1433-2965
0937-941X
DOI: 10.1007/s00198-003-1493-1
Popis: Intestinal calcium absorption accounts for 60% of the variance in calcium balance and is therefore a potentially very important determinant of bone status. Whether measured by the balance technique or with radiocalcium, it is known to be significantly reduced in postmenopausal women with vertebral and hip fractures. By contrast, there is very little information about calcium absorption in other types of postmenopausal fracture. We now report a series of 549 untreated, Caucasian postmenopausal women in whom we recorded prevalent fractures, measured radiocalcium absorption, and obtained radiographs of the lateral thoracic and lumbar spine. Of these women, 172 had no prevalent fractures, showed normal spine radiographs, and served as controls; 72 had one or more peripheral fractures but normal spine radiographs; 147 had one or more wedged or crushed vertebrae but no peripheral fractures; and 158 had a history of peripheral fracture and one or more fractured vertebrae. Age-adjusted radiocalcium absorption was significantly lower in the two groups with spinal fractures than in the controls ( P
Databáze: OpenAIRE