Sulfonate improves water solubility and cell selective toxicity and alters the lysozyme binding activity of half sandwich Rh(iii ) complexes
| Autor: | Ola R. Shehab, Ahmed M. Mansour, Krzysztof Radacki |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cryptococcus neoformans
Benzimidazole Aqueous solution biology 010405 organic chemistry Chemistry Stereochemistry 010402 general chemistry Ligand (biochemistry) biology.organism_classification 01 natural sciences Ruthenium 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound HEK293 Cells Sulfonate Solubility Coordination Complexes Toxicity Humans Muramidase Lysozyme Cytotoxicity |
| Zdroj: | Dalton Transactions. 50:10701-10706 |
| ISSN: | 1477-9234 1477-9226 |
| DOI: | 10.1039/d1dt00979f |
| Popis: | Introduction of the propyl-sulfonic acid group at N1 of the coordinated 2-(2-pyridyl)benzimidazole ligand (L) in [RhCl(η5-C5Me5)L](CF3SO3) gives rise to a water-soluble complex, which can bind to the model protein lysozyme via non-covalent interactions. The complex shows selective moderate toxicity against Cryptococcus neoformans (MIC = 21.6–43.3 μM) and exhibits no cytotoxicity to healthy HEK293 cells. |
| Databáze: | OpenAIRE |
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