Vitamin D and functional arterial parameters in postmenopausal women with metabolic syndrome
| Autor: | Jolanta Dadonienė, Aleksandras Laucevičius, Goda Kalinauskaitė, Egidija Rinkūnienė, Jolita Badarienė, Alma Čypienė, Vaiva Kumpauskaitė, Ieva Sakaitė, Jelizaveta Burca |
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| Rok vydání: | 2016 |
| Předmět: |
Vitamin
medicine.medical_specialty Mean arterial pressure Blood Pressure 030204 cardiovascular system & hematology vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D Aged Demography Metabolic Syndrome Creatinine medicine.diagnostic_test business.industry Arteries General Medicine Middle Aged medicine.disease Postmenopause Endocrinology chemistry Arterial stiffness Female Seasons Metabolic syndrome business Lipid profile |
| Zdroj: | Advances in Medical Sciences. 61:224-230 |
| ISSN: | 1896-1126 |
| DOI: | 10.1016/j.advms.2015.12.007 |
| Popis: | Our cross sectional study aimed to identify the relation between vitamin D level and functional arterial parameters in postmenopausal women with metabolic syndrome.100 postmenopausal women at age 50-65 with diagnosed metabolic syndrome were included in this study. Laboratory tests were performed to determine lipid profile, serum glucose, creatinine, C-reactive protein, serum levels of 25(OH) D, ionized calcium and urine albumin/creatinine ratio. Also non-invasive assessment of arterial function (arterial stiffness, flow-mediated dilatation and carotid artery ultrasound examinations) was performed.The mean vitamin D blood concentration was 47.4±16.9nmol/l. The prevalence of modest insufficiency and deficiency of vitamin D was 62%. Vitamin D concentration in samples assembled from January to March was significantly lower than concentration levels from September to November. No significant relationship was observed between vitamin D and endothelial function, arterial stiffness, carotid intima-media thickness. Week negative correlation was stated between mean arterial pressure and 25(OH) D concentration (p=0.04). A positive correlation was found between high density lipoprotein cholesterol and vitamin 25(OH) D (r=0.3, p0.05). No significant difference between 25(OH) D and other lipoproteins, calcium ions, glucose, albumin/creatinine ratio and C-reactive protein blood concentrations were found.The prevalence of vitamin D deficiency in postmenopausal women with metabolic syndrome is high. No relation was found between vitamin D levels and parameters that indicate atherosclerotic vascular lesions. Nevertheless our study revealed the relation between concentrations of vitamin D and mean blood pressure and high density lipoprotein cholesterol. |
| Databáze: | OpenAIRE |
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