Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice
| Autor: | Shakir D. AlSharari, F. Ivy Carroll, S. Stevens Negus, Pretal P. Muldoon, Deniz Bagdas, M. Imad Damaj |
|---|---|
| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi., Bağdaş, Deniz |
| Rok vydání: | 2016 |
| Předmět: |
Male
Narcotic analgesic agent 0301 basic medicine Ketoprofen Mouse Piperidine derivative Physiology Antagonists and inhibitors Pharmacology Grimace Scale Buprenorphine Animals Mice chemistry.chemical_compound Aversion 0302 clinical medicine Piperidines Preclinical assays Tetrahydroisoquinolines Pharmacological blocking Stretching Avoidance learning Priority journal Analgesics Morphine Depression 3 4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide (trans)-Isomer Behavior animal JDTic Amygdala Mice inbred ICR Visceral pain Kappa opiate receptor medicine.symptom μ-opioid receptor Analgesics opioid Animal behavior medicine.drug Adult Agonist medicine.drug_class Pain Activation Negative affective component Animal-models 3 4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide Mu opiate receptor Neurosciences & neurology Acetic acid 7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3 4-dimethyl-1-piperidinyl)methyl)-2-methylpropyl)-1 2 3 4-tetrahydro-3-isoquinolinecarboxamide Pathophysiology κ-opioid receptor Article 03 medical and health sciences Cellular and Molecular Neuroscience Drug potency Receptors opioid mu medicine Animal model Animal experiment Conditioned place aversion Drug effects Pharmacology & pharmacy Receptors opioid kappa Animal Avoidance behavior business.industry Analgesic efficacy Neurosciences Antagonist Bed nucleus Tetrahydroisoquinoline derivative Anti-inflammatory agents non-steroidal Nonhuman Institute for cancer research mouse Nonsteroid antiinflammatory agent Drug effect stomatognathic diseases Lithium chloride 030104 developmental biology chemistry Stria terminalis 3 4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate business Controlled study 030217 neurology & neurosurgery Agonists |
| Zdroj: | Neuropharmacology. 102:236-243 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/j.neuropharm.2015.11.024 |
| Popis: | Pain encompasses both a sensory as well as an affective dimension and these are differentially processed in the brain and periphery. It is therefore important to develop animal models to reflect the non-reflexive assays in pain. In this study, we compared effects of the mu opioid receptor agonist morphine, the nonsteroidal anti-inflammatory drug ketoprofen and the kappa receptor opioid agonist U50,488H and antagonist JDTic on acetic acid-induced stretching and acetic acid-induced aversion in the condition place aversion (CPA) test in male ICR mice. Intraperitoneal administration of acetic acid (0.32-1%) was equipotent in stimulating stretching and CPA. Ketoprofen, morphine and U50,488H all inhibited the acid induced stretching. Ketoprofen and morphine also blocked the acid-induced CPA but U50,488H failed to do so. The reversal ability of ketoprofen and morphine on acid-induced CPA is unique to pain-stimulated place aversion since these drugs failed to reduce non-noxious LiCl-induced CPA. Overall, this study characterized and validated a preclinical mouse model of pain-related aversive behavior that can be used to assess genetic and biological mechanisms of pain as well as improving the predictive validity of preclinical studies on candidate analgesics. United States Department of Health & Human Services National Institutes of Health (NIH) - USA - R01DA-019377 - R01NS070715 - R01DA030404 NIH National Institute of Neurological Disorders & Stroke (NINDS) - R01NS070715 NIH National Institute on Drug Abuse (NIDA) - R01DA030404 European Commission |
| Databáze: | OpenAIRE |
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