Studies on the role of nicotinic acetylcholine receptors in the discriminative and aversive stimulus properties of ethanol in the rat
| Autor: | Eliza Koros, Roman Stefanski, Jerzy Piasecki, Przemyslaw Bienkowski, Wojciech Kostowski |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Nicotine Nicotinic Antagonists Pharmacology Stimulus (physiology) Mecamylamine Receptors Nicotinic Discrimination Psychological medicine Avoidance Learning Animals Pharmacology (medical) Nicotinic Agonists Rats Wistar Biological Psychiatry Dose-Response Relationship Drug Ethanol Chemistry Central Nervous System Depressants Rats Psychiatry and Mental health Nicotinic acetylcholine receptor Nicotinic agonist Neurology Taste Taste aversion Neurology (clinical) Aversive Stimulus Stimulus control medicine.drug |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 8(2) |
| ISSN: | 0924-977X |
| Popis: | The role of the nicotinic acetylcholine receptor (nAChR) in the discriminative and aversive stimulus effects of ethanol was studied in rats. In the operant drug discrimination procedure the rats were trained to discriminate between 1.0 g/kg ethanol and saline under the FR10 schedule of sweetened milk reinforcement. Neither the nAChR agonist, nicotine (0.1–0.6 mg/kg) nor the nAChR antagonist, mecamylamine (3.0–6.0 mg/kg) substituted for the ethanol stimulus. Moreover, mecamylamine (0.5–6.0 mg/kg) did not antagonise the ethanol stimulus. The cross-familiarisation conditioned taste aversion procedure was used as an alternative method to study stimulus resemblance between ethanol and nicotine. Six daily injections of nicotine (0.6 mg/kg) significantly decreased a subsequent ethanol-induced taste aversion conditioning. The aversive stimulus effects of ethanol were investigated with the conditioned taste aversion (CTA) paradigm. Mecamylamine (1.0–3.0 mg/kg) did not attenuate an ethanol-induced CTA. These results suggest that: (1) nAChRs are not primarily involved in the discriminative stimulus effects of ethanol when studied with the operant drug discrimination test; (2) nAChRs are not critically involved in the ethanol-induced CTA. |
| Databáze: | OpenAIRE |
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