Pattern Visual Evoked Potential, Pattern Electroretinogram, and Retinal Nerve Fiber Layer Thickness in Patients with Migraine during and after Aura

Autor:	Yousra Ahmed Thabet Farweez, Momen Mahmoud Hamdi, Amany Abd El-Fattah El-Shazly, Noha Ezzat EL-Sherbiny
Rok vydání:	2017
Předmět:	Adult Male Retinal Ganglion Cells medicine.medical_specialty Time Factors genetic structures Aura Migraine Disorders Nerve fiber layer Retina 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Nerve Fibers 0302 clinical medicine Ophthalmology Electroretinography medicine Humans Evoked potential Retrospective Studies Epilepsy medicine.diagnostic_test business.industry Retinal medicine.disease eye diseases Sensory Systems Migraine with aura medicine.anatomical_structure P100 Latency Migraine chemistry Anesthesia 030221 ophthalmology & optometry Evoked Potentials Visual Female sense organs medicine.symptom business Tomography Optical Coherence 030217 neurology & neurosurgery Follow-Up Studies
Zdroj:	Current Eye Research. 42:1327-1332
ISSN:	1460-2202 0271-3683
DOI:	10.1080/02713683.2017.1319490
Popis:	To study pattern visual evoked potential (PVEP), pattern electroretinogram (PERG), and retinal nerve fiber layer (RNFL) thickness in patients with migraine during and after aura.We included 60 eyes of 60 patients with migraine (Group 1) and 30 healthy volunteers (30 eyes) as controls (Group 2). Group 1 was studied twice, during a visual aura (1-a) and in between attacks (1-b). All participants underwent full ophthalmological examination, PVEP, PERG, and optical coherence tomographyOCT imaging of the RNFL thickness for each patient.RNFL thickness was found to be thinner in patients during the aura compared to controls. It increased significantly post-aura but remained lower than the controls. Prolonged P100 latency and decreased amplitude were found in patients during aura compared to controls with significant change in between attacks to values comparable to the controls. We found prolonged N95 latency and decreased amplitude in patients during aura compared to controls with significant change post-aura to values comparable to the controls. There was positive correlation between average RNFL thicknesses and VA and spherical equivalent; but it showed negative correlation with duration of migraine, attack duration, and aura duration. Multiple regression analysis showed that the most important determinants of average RNFL thickness in patients of migraine were attack and aura duration (beta = -0.21 and -0.26 and p = 0.03 and 0.04, respectively).Migraine attacks impose both functional and structural retinal changes. The functional changes are fully reversible after the aura but not the structural ones. So, vigorous prevention of migraine attacks would be protective for retina.
Databáze:	OpenAIRE
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