Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals: Associations with Insulin Sensitivity
| Autor: | Erik Ingelsson, Lars Lind, Anubha Mahajan, Andrew P. Morris, Ulf Risérus, Cecilia M. Lindgren, Matti Marklund |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Fatty Acid Desaturases Male Insulin Resistance/genetics Adipose tissue Genome-wide association study Genetic Variation/physiology chemistry.chemical_compound Delta-5 Fatty Acid Desaturase Cluster Analysis Longitudinal Studies chemistry.chemical_classification Nutrition and Dietetics Genome-wide association study (GWAS) Adipose Tissue/enzymology Glucose clamp technique Middle Aged Insulin sensitivity 3. Good health adipose tissue Näringslära cholesterol ester Genetic Loci/genetics Receptor Melanocortin Type 4 Cholesterol Esters lcsh:Nutrition. Foods and food supply Fatty Acid Desaturases/genetics medicine.medical_specialty FADS1 FADS2 lcsh:TX341-641 Article 03 medical and health sciences Internal medicine medicine Humans Receptor Melanocortin Type 4/genetics Genetic association Sweden Cholesterol Esters/blood Cholesterol Fatty acid Genetic Variation 030104 developmental biology Endocrinology chemistry Genetic Loci Glucose Clamp Technique fatty acid Insulin Resistance desaturase Food Science Genome-Wide Association Study |
| Zdroj: | Nutrients Volume 10 Issue 11 Marklund, M, Morris, A P, Mahajan, A, Ingelsson, E, Lindgren, C M, Lind, L & Risérus, U 2018, ' Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals : Associations with Insulin Sensitivity ', Nutrients, vol. 10, no. 11, E1791 . https://doi.org/10.3390/nu10111791 Nutrients, Vol 10, Iss 11, p 1791 (2018) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu10111791 |
| Popis: | Fatty acid desaturases (FADS) catalyze the formation of unsaturated fatty acids and have been related to insulin sensitivity (IS). FADS activities differ between tissues and are influenced by genetic factors that may impact the link to IS. Genome-wide association studies of &delta 5-desaturase (D5D), &delta 6-desaturase (D6D) and stearoyl-CoA desaturase-1 (SCD) activities (estimated by product-to-precursor ratios of fatty acids analyzed by gas chromatography) in serum cholesterol esters (n = 1453) and adipose tissue (n = 783, all men) were performed in two Swedish population-based cohorts. Genome-wide significant associated loci were evaluated for associations with IS measured with a hyperinsulinemic euglycemic clamp (n = 554). Variants at the FADS1 were strongly associated with D5D in both cholesterol esters (p = 1.9 × 10&minus 70) and adipose tissue (p = 1.1 × 27). Variants in three further loci were associated with D6D in cholesterol esters (FADS2, p = 3.0 × 67 PDXDCI, p = 4.8 × 8 and near MC4R, p = 3.7 × 8) but no associations with D6D in adipose tissue attained genome-wide significance. One locus was associated with SCD in adipose tissue (PKDL1, p = 2.2 × 19). Genetic variants near MC4R were associated with IS (p = 3.8 × 3). The FADS cluster was the main genetic determinant of estimated FADS activity. However, fatty acid (FA) ratios in adipose tissue and cholesterol esters represent FADS activities in separate tissues and are thus influenced by different genetic factors with potential varying effects on IS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|