Relationship Between Genomic Damage and Clinical Features in Dialysis Patients
| Autor: | Ayse Serap Yalin, Mehmet Riza Altiparmak, Aydın Tunçkale, Bahadir Batar, Mehmet Güven, Sinan Trabulus, Gülgün S. Güven |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Pathology medicine.medical_treatment Gastroenterology Peritoneal dialysis Internal medicine medicine Humans Genetics (clinical) Dialysis Univariate analysis Micronucleus Tests Genome Human business.industry Case-control study General Medicine Middle Aged Case-Control Studies Micronucleus test Biomarker (medicine) Female Hemodialysis Micronucleus business DNA Damage |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 17:202-206 |
| ISSN: | 1945-0257 1945-0265 |
| Popis: | Patients with end-stage renal disease display enhanced genomic damage. We investigated the presence of genomic damage in the peripheral lymphocytes by using the micronucleus (MN) test and the factors associated with the MN frequency in hemodialysis (HD) and peritoneal dialysis (PD) patients. We studied 121 dialysis patients (60 HD and 61 PD) and 129 age- and gender-matched healthy controls. The MN analysis, used as a biomarker of chromosomal/DNA damage, was performed in peripheral lymphocytes by the cytokinesis-block method. Univariate analysis showed a significantly higher MN frequency in all patients in comparison with the controls (7.6% ± 0.3% vs. 4.9% ± 0.2%, respectively, p |
| Databáze: | OpenAIRE |
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