Disappearance curves of tumor markers after radical surgery
| Autor: | Enrico Ruffini, Pivetti S, Ciocia E, Piantino P, Scappaticci E, Cavallo A, Rapellino M, Pecchio F, Sergio Baldi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms Clinical Biochemistry Urology Adenocarcinoma Malignancy Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Carcinoembryonic antigen Antigens Neoplasm Stomach Neoplasms Neoplasms medicine Carcinoma Biomarkers Tumor Humans Clinical significance Antigens Tumor-Associated Carbohydrate Tissue Polypeptide Antigen Radical surgery Tumor marker Aged Epithelioma biology business.industry Middle Aged medicine.disease Surgery Carcinoembryonic Antigen 030104 developmental biology Oncology 030220 oncology & carcinogenesis Colonic Neoplasms biology.protein Carcinoma Squamous Cell CA19-9 Female business Peptides Half-Life |
| Zdroj: | Scopus-Elsevier |
| Popis: | CEA serum levels were sampled from 15 patients with lung carcinoma, 12 patients with colon carcinoma, and 5 patients with gastric carcinoma before and after radical excision of the malignancy. In addition, TPA serum levels were measured in 7 patients with lung carcinoma and CA 19.9 serum levels in 9 patients with colon carcinoma, before and after curative surgery. Irrespective of the primary malignancy, a CEA half-life of approximately 3 days was calculated. The normalization time was related to the preoperative level of the marker, being longer when the preoperative CEA level was > 20 ng/ml. The TPA half-life was slightly longer than 1 day, ranging from less than 1 day to more than 3 days, with a normalization time of about 20 days. The CA 19.9 half-life was slightly longer than 1 day with variations from less than 1 day to about 3 days. Many factors, especially associated inflammatory processes and hepatic clearance imbalances, may influence marker kinetics in the postoperative period. A correct evaluation of the clinical significance of tumor marker half-life after radical surgery will require a larger number of patients as well as careful and prolonged follow-up. |
| Databáze: | OpenAIRE |
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