Absolute configuration of (+)-(S)-2-(5-fluoro-2-methoxy-1,4-benzodioxan-2-yl)imidazolinium bromide
Autor: | Monique Tillard, Jean-Paul Ribet, Renaud C. Belin, Jean-Louis Maurel |
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Rok vydání: | 2000 |
Předmět: |
Bicyclic molecule
Stereochemistry Hydrogen bond Absolute configuration Imidazoles Molecular Conformation Ether General Medicine Crystal structure Crystallography X-Ray Medicinal chemistry General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Benzodioxan chemistry Bromide Receptors Adrenergic alpha-2 Molecule Adrenergic alpha-Antagonists |
Zdroj: | Acta crystallographica. Section C, Crystal structure communications. 57(Pt 4) |
ISSN: | 0108-2701 |
Popis: | The title compound, C(12)H(14)FN(2)O(3)(+).Br(-), crystallizes in the non-centrosymmetric P2(1)2(1)2(1) space group. The absolute configuration of the pharmacologically active molecule could be resolved in the hydrobromide salt, the structure of which is reported. The molecule of the title compound has the S configuration. The molecular packing in the crystal is stabilized by weak N-H.Br [N.Br = 3.240 (4) and 3.302 (4) A] hydrogen bonding. |
Databáze: | OpenAIRE |
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