Fluoxetine and 8-OH-DPAT in the lateral septum enhances and impairs retention of an inhibitory avoidance response in rats
| Autor: | Hsin-Yi Chen, Keng-Chen Liang, Eminy H.Y. Lee, W. R. Lin, W. H. Shiu |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Ketanserin Tetrahydronaphthalenes Experimental and Cognitive Psychology Ritanserin Injections Behavioral Neuroscience Fluoxetine Internal medicine Avoidance Learning medicine Animals 5-HT receptor Zimelidine 8-Hydroxy-2-(di-n-propylamino)tetralin Brain Mapping Dose-Response Relationship Drug Chemistry 5-HT2 receptor Zimeldine Retention Psychology Septal nuclei Rats Inbred Strains Fear Rats Endocrinology medicine.anatomical_structure Receptors Serotonin Mental Recall Autoreceptor Septum Pellucidum Serotonin medicine.drug |
| Zdroj: | Physiology & Behavior. 51:681-688 |
| ISSN: | 0031-9384 |
| Popis: | The present study investigated the role of lateral septal serotonin (5HT) in memory consolidation and the subtype of 5HT receptors involved in this process. Rats with cannulae implanted bilaterally into the lateral septum were trained in an inhibitory avoidance task. Immediately after training, the septal serotonergic function was manipulated by pharmacological agents selectively blocking 5HT reuptake (fluoxetine and zimelidine), antagonizing 5HT2 receptors (ketanserin and ritanserin), or activating 5HT1A receptors, respectively. Results indicated that direct fluoxetine infusions into the lateral septum at a dose of 6 micrograms/0.5 microliter and zimelidine at a dose of 5 micrograms/0.5 microliter both markedly enhanced memory. Intralateral septal injections of ketanserin (0.3 microgram/0.5 microliter and 0.5 microgram/0.5 microliter) and ritanserin (0.3 microgram/0.5 microliter and 0.6 microgram/0.5 microliter) did not have a significant effect by themselves on memory, and neither did they attenuate the memory-facilitating effect of fluoxetine in the same area. Intralateral septal infusions of 8-hydroxy-2-(di-n-propylamino)tetralin at 5 micrograms/0.5 microliter significantly impaired memory retention. These findings altogether support the notion that the lateral septal nuclei of rats are involved in the memory processes of inhibitory avoidance learning. Furthermore, postsynaptic 5HT receptor activation (not the 5HT2 receptor subtype) probably exerts a facilitatory effect while presynaptic 5HT1A receptor activation exerts an impairing effect on the memory consolidation process, probably due to autoreceptor inhibition of 5HT release. |
| Databáze: | OpenAIRE |
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