Genome-wide SNP analysis reveals distinct origins of **Trypanosoma evansi** and **Trypanosoma equiperdum**
| Autor: | Bruno Goddeeris, Julien Cauchard, Jonathan M. Wilkes, Kris Laukens, Hadush Birhanu, Jean-Claude Dujardin, Philippe Büscher, Bart Cuypers, Frederik Van den Broeck, Filip Claes, Nick Van Reet, Conor J. Meehan, Stijn Deborggraeve |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Trypanosoma Genes Protozoan Trypansoma equiperdum 030231 tropical medicine Trypanosoma brucei phylogeny Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Phylogenetics parasitic diseases Genetics medicine African trypanosomiasis SNP analysis Biology Ecology Evolution Behavior and Systematics Trypanozoon whole genome sequencing Trypanosoma evansi biology Trypanosoma brucei rhodesiense Africa Eastern biology.organism_classification medicine.disease Surra Virology 3. Good health Africa Western 030104 developmental biology Trypanosoma equiperdum Human medicine Genome Protozoan Genome-Wide Association Study Research Article |
| Zdroj: | Genome Biology and Evolution |
| ISSN: | 1759-6653 |
| Popis: | Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and T. b. rhodesiense cause human African trypanosomiasis, while T. b. brucei, T. evansi and T. equiperdum are responsible for nagana, surra and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses have been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission. [Abstract copyright: © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.] |
| Databáze: | OpenAIRE |
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