Mechanisms of pollutant-induced toxicity in skin and detoxification: Anti-pollution strategies and perspectives for cosmetic products
| Autor: | C. Egles, F. Richard, T. Creusot, S. Catoire, H. Ficheux |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pollution
Premature aging Ultraviolet Rays Skin Absorption media_common.quotation_subject Pharmaceutical Science Human skin Cosmetics medicine.disease_cause Antioxidants World health Xenobiotics Sebaceous Glands Ozone Smoke Detoxification Environmental health medicine Humans Skin media_common Inflammation Pharmacology Pollutant Emollients business.industry Drug Synergism Lipids Skin Aging Oxidative Stress Inactivation Metabolic Toxicity Cytokines Environmental Pollutants Particulate Matter Drug Eruptions business Hair Follicle Oxidative stress DNA Damage |
| Zdroj: | Annales Pharmaceutiques Françaises. 77:446-459 |
| ISSN: | 0003-4509 |
| Popis: | With the development of industry and increase in road traffic, atmospheric pollution has reached unprecedented levels in many regions of the world. Concentrations of pollutants are often far beyond the recommendations of the World Health Organization. Skin, as the first interface between the human body and its environment, is one of the main organs exposed to pollutants and to other environmental factors such as UV irradiation. As much as the effects of pollution and UV irradiation on human skin have been described, the underlying mechanisms remain to be elucidated. This state of the art study aims at exposing the numerous adverse effects of UV and pollution as well as their mode of action on skin. We summarize how these environmental factors negatively impact skin cells: by upregulating xenobiotic metabolism (and bioactivation) and inducing oxidative stress and inflammation, leading to premature aging and a disrupted barrier function. Consequently, we suggest adapted protective measures for the cosmetic industry to support anti-pollution claims. |
| Databáze: | OpenAIRE |
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