Biochemistry and computer generated graph comparison of the structural and nonstructural proteins of spanish-1918 Influenza, pandemic-2009, and bird flu viruses
| Autor: | Ida Bagus Kade Suardana, Wisnu W. Mahardika, I Gusti Ngurah Kade Mahardika, Nyoman Suartha, Gusti Ayu Yuniati Kencana, Nyoman S. Budayanti |
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| Rok vydání: | 2019 |
| Předmět: |
Protein Conformation
alpha-Helical viruses Genome Viral Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Birds Viral Proteins Influenza A Virus H1N1 Subtype Influenza Human Pandemic Disease Transmission Infectious medicine Animals Humans Computer Simulation Pandemics Genetics Influenza A Virus H5N1 Subtype Bird flu Strain (biology) Pandemic influenza virus diseases Influenza pandemic Influenza A virus subtype H5N1 Influenza Vaccines Influenza in Birds GenBank Influenza Pandemic 1918-1919 |
| Zdroj: | Acta Biochimica Polonica. |
| ISSN: | 1734-154X 0001-527X |
| DOI: | 10.18388/abp.2019_2795 |
| Popis: | The potential emergence of deadly pandemic influenza viruses is unpredictable and most have emerged with no forewarning. The distinct epidemiological and pathological patterns of the Spanish (H1N1), pandemic-2009 (H1N1), and avian influenza (H5N1), known as bird flu, viruses may allow us to develop a ‘template’ for possible emergence of devastating pandemic strains. Here, we provide a detailed molecular dissection of the structural and nonstructural proteins of this triad of viruses. GenBank data for three representative strains were analyzed to determine the polymorphic amino acids, genetic distances, and isoelectric points, hydrophobicity plot, and protein modeling of various proteins. We propose that the most devastating pandemic strains may have full-length PB1-F2 protein with unique residues, highly cleavable HA, and a basic NS1. Any newly emerging strain should be compared with these three strains, so that resources can be directed appropriately. |
| Databáze: | OpenAIRE |
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